Abstract
Asthma, seen primarily as an inflammatory disease with secondary airway hyper-responsiveness, causes symptoms through contraction of the airway's smooth muscles. The management of chronic asthma relies on bronchodilators for symptomatic relief of bronchospasm, while primary therapy is used to either prevent or reverse the inflammatory component of the disease. Anti-inflammatory therapeutic strategies include environmental control (where relevant), sodium cromoglycate (where appropriate), and both inhaled and oral glucocorticosteroids. Management of acute severe asthma is similar; bronchodilators are used to ”buy time” while systemic corticosteroids control the inflammatory process.
Keywords: bronchial asthma, respiratory system
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Selected References
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- Cockcroft D. W. Airway hyperresponsiveness: therapeutic implications. Ann Allergy. 1987 Dec;59(6):405–414. [PubMed] [Google Scholar]
- Cockcroft D. W. Cigarette smoking, airway hyperresponsiveness, and asthma. Chest. 1988 Oct;94(4):675–676. doi: 10.1378/chest.94.4.675. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Murdock K. Y. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J Allergy Clin Immunol. 1987 May;79(5):734–740. doi: 10.1016/0091-6749(87)90204-1. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W. Nonallergic airway responsiveness. J Allergy Clin Immunol. 1988 Jan;81(1):111–119. doi: 10.1016/0091-6749(88)90229-1. [DOI] [PubMed] [Google Scholar]
- Furukawa C. T., DuHamel T. R., Weimer L., Shapiro G. G., Pierson W. E., Bierman C. W. Cognitive and behavioral findings in children taking theophylline. J Allergy Clin Immunol. 1988 Jan;81(1):83–88. doi: 10.1016/0091-6749(88)90224-2. [DOI] [PubMed] [Google Scholar]
- Kerrebijn K. F., van Essen-Zandvliet E. E., Neijens H. J. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol. 1987 Apr;79(4):653–659. doi: 10.1016/s0091-6749(87)80163-x. [DOI] [PubMed] [Google Scholar]
- Kirby J. G., Hargreave F. E., Gleich G. J., O'Byrne P. M. Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis. 1987 Aug;136(2):379–383. doi: 10.1164/ajrccm/136.2.379. [DOI] [PubMed] [Google Scholar]
- Lam S., Wong R., Yeung M. Nonspecific bronchial reactivity in occupational asthma. J Allergy Clin Immunol. 1979 Jan;63(1):28–34. doi: 10.1016/0091-6749(79)90158-1. [DOI] [PubMed] [Google Scholar]
- Leung K. B., Flint K. C., Brostoff J., Hudspith B. N., Johnson N. M., Pearce F. L. A comparison of nedocromil sodium and sodium cromoglycate on human lung mast cells obtained by bronchoalveolar lavage and by dispersion of lung fragments. Eur J Respir Dis Suppl. 1986;147:223–226. [PubMed] [Google Scholar]
- Löwhagen O., Rak S. Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season. J Allergy Clin Immunol. 1985 Apr;75(4):460–467. doi: 10.1016/s0091-6749(85)80018-x. [DOI] [PubMed] [Google Scholar]
- MacDonald G. F. An overview of ketotifen. Chest. 1982 Jul;82(1 Suppl):30S–32S. doi: 10.1378/chest.82.1.30s. [DOI] [PubMed] [Google Scholar]
- O'Byrne P. M. Airway inflammation and airway hyperresponsiveness. Chest. 1986 Oct;90(4):575–577. doi: 10.1378/chest.90.4.575. [DOI] [PubMed] [Google Scholar]
- Platts-Mills T. A., Tovey E. R., Mitchell E. B., Moszoro H., Nock P., Wilkins S. R. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet. 1982 Sep 25;2(8300):675–678. doi: 10.1016/s0140-6736(82)90709-7. [DOI] [PubMed] [Google Scholar]
- Sears M. R. Increasing asthma mortality--fact or artifact? J Allergy Clin Immunol. 1988 Dec;82(6):957–960. doi: 10.1016/0091-6749(88)90130-3. [DOI] [PubMed] [Google Scholar]