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Canadian Family Physician logoLink to Canadian Family Physician
. 1989 Sep;35:1829–1831.

Does Antihypertensive Therapy Need to be Life-Long?

Jacques Lemelin
PMCID: PMC2280900  PMID: 21249061

Abstract

The author reviews the evidence for and against decreasing or discontinuing antihypertensive therapy on known hypertensive patients once their blood pressure has been brought under control. The evidence supports a trial of decreasing and, in many cases, discontinuing antihypertensive medication. Although there are no established protocols for cessation of therapy, the author discusses suggestions in the literature.

Keywords: antihypertensive therapy, cardiovascular disease, hypertension, pharmaceutical therapy

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alderman M. H., Davis T. K., Gerber L. M. Step-down therapy for hypertension. Results in a community-based program. Postgrad Med. 1985 May 15;77(7):89-92, 96-9. doi: 10.1080/00325481.1985.11699012. [DOI] [PubMed] [Google Scholar]
  2. Fernandez P. G., Kim B. K., Galway A. B., Sharma J. N. Separation of essential hypertensive patients based on blood pressure responses after the withdrawal of antihypertensive agents by step-wise discriminant analysis. Curr Med Res Opin. 1983;8(7):509–517. doi: 10.1185/03007998309109790. [DOI] [PubMed] [Google Scholar]
  3. Finnerty F. A., Jr Step-down therapy for hypertension. Results of withdrawal from multiple drugs and from a single drug. Postgrad Med. 1985 May 15;77(7):78–85. doi: 10.1080/00325481.1985.11699011. [DOI] [PubMed] [Google Scholar]
  4. Finnerty F. A., Jr Step-down treatment of mild systemic hypertension. Am J Cardiol. 1984 May 1;53(9):1304–1307. doi: 10.1016/0002-9149(84)90084-5. [DOI] [PubMed] [Google Scholar]
  5. Graham R. M. Considerations in the long-term treatment of hypertension. Clin Ther. 1983;5(3):224–233. [PubMed] [Google Scholar]
  6. Langford H. G., Blaufox M. D., Oberman A., Hawkins C. M., Curb J. D., Cutter G. R., Wassertheil-Smoller S., Pressel S., Babcock C., Abernethy J. D. Dietary therapy slows the return of hypertension after stopping prolonged medication. JAMA. 1985 Feb 1;253(5):657–664. [PubMed] [Google Scholar]
  7. Levinson P. D., Khatri I. M., Freis E. D. Persistence of normal BP after withdrawal of drug treatment in mild hypertension. Arch Intern Med. 1982 Dec;142(13):2265–2268. doi: 10.1001/archinte.142.13.2265. [DOI] [PubMed] [Google Scholar]

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