Abstract
In this study, 801 pharyngeal specimens were cultured for group A streptococci and tested with the Biostar Strep A Optical Immunoassay (Strep A OIA). The respective sensitivities and specificities were as follows: culture, 97.1 and 100%; Strep A OIA, 91.5 and 94.8%. Of the 801 specimens, 597 were also tested with the Abbott TestPack Strep A Assay (TP-ST). For those specimens tested by all three methods, the respective sensitivities and specificities were as follows: culture, 98.1 and 100%; Strep A OIA, 92.3 and 95.4%; and TP-ST, 79.4 and 100%. The Strep A OIA is significantly more sensitive than TP-ST and compares favorably with culture.
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Selected References
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- Anhalt J. P., Heiter B. J., Naumovitz D. W., Bourbeau P. P. Comparison of three methods for detection of group A streptococci in throat swabs. J Clin Microbiol. 1992 Aug;30(8):2135–2138. doi: 10.1128/jcm.30.8.2135-2138.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Avendaño L. F., Larrañaga C., Palomino M. A., Gaggero A., Montaldo G., Suárez M., Díaz A. Community- and hospital-acquired respiratory syncytial virus infections in Chile. Pediatr Infect Dis J. 1991 Aug;10(8):564–568. doi: 10.1097/00006454-199108000-00003. [DOI] [PubMed] [Google Scholar]
- Bourbeau P. P., Heiter B. J., Anhalt J. P., Naumovitz D. W. Comparison of direct specimen testing utilizing TestPack strep A with testing of specimens following a two-hour broth enrichment. Diagn Microbiol Infect Dis. 1993 Aug-Sep;17(2):93–96. doi: 10.1016/0732-8893(93)90018-3. [DOI] [PubMed] [Google Scholar]
- Danjani A. S., Bisno A. L., Chung K. J., Durack D. T., Gerber M. A., Kaplan E. L., Millard H. D., Randolph M. F., Shulman S. T., Watanakunakorn C. Prevention of rheumatic fever. A statement for health professionals by the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association. Circulation. 1988 Oct;78(4):1082–1086. doi: 10.1161/01.cir.78.4.1082. [DOI] [PubMed] [Google Scholar]
- Facklam R. R. Specificity study of kits for detection of group A streptococci directly from throat swabs. J Clin Microbiol. 1987 Mar;25(3):504–508. doi: 10.1128/jcm.25.3.504-508.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harbeck R. J., Teague J., Crossen G. R., Maul D. M., Childers P. L. Novel, rapid optical immunoassay technique for detection of group A streptococci from pharyngeal specimens: comparison with standard culture methods. J Clin Microbiol. 1993 Apr;31(4):839–844. doi: 10.1128/jcm.31.4.839-844.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heiter B. J., Bourbeau P. P. Comparison of the Gen-Probe Group A streptococcus Direct Test with culture and a rapid streptococcal antigen detection assay for diagnosis of streptococcal pharyngitis. J Clin Microbiol. 1993 Aug;31(8):2070–2073. doi: 10.1128/jcm.31.8.2070-2073.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kellogg J. A., Landis R. C., Nussbaum A. S., Bankert D. A. Performance of an enzyme immunoassay test and anaerobic culture for detection of group A streptococci in a pediatric practice versus a hospital laboratory. J Pediatr. 1987 Jul;111(1):18–21. doi: 10.1016/s0022-3476(87)80335-9. [DOI] [PubMed] [Google Scholar]
- Kellogg J. A. Suitability of throat culture procedures for detection of group A streptococci and as reference standards for evaluation of streptococcal antigen detection kits. J Clin Microbiol. 1990 Feb;28(2):165–169. doi: 10.1128/jcm.28.2.165-169.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]