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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1995 Jun;33(6):1492–1495. doi: 10.1128/jcm.33.6.1492-1495.1995

Seroepizootiology of Helicobacter pylori gastric infection in nonhuman primates housed in social environments.

A Dubois 1, N Fiala 1, R H Weichbrod 1, G S Ward 1, M Nix 1, P T Mehlman 1, D M Taub 1, G I Perez-Perez 1, M J Blaser 1
PMCID: PMC228202  PMID: 7650173

Abstract

We determined the seroepizootiology of Helicobacter pylori infection in rhesus monkeys. Plasma was obtained from 196 animals (age range, 1 to 22 years) that were housed in social environments, either in indoor gang cages, in outdoor corrals, or in free-ranging forested conditions. Plasma immunoglobulin G levels were determined with a specific enzyme-linked immunosorbent assay, and the cutoff immunoglobulin G value for H. pylori seropositivity was determined from a study of 25 monkeys whose infection status was assessed by light microscopy and culture. One-year-old animals of both genders in all housing conditions had the lowest rate of positivity (60% in monkeys 1 year old versus 81% in monkeys 2 to 10 years old, P = 0.026). In addition, females tended to have higher rates of positivity than males. Seroconversion during a 1-year observation period occurred in 7 (28%) of 25 seronegative animals. Seroreversion occurred in 3 (4%) of the 78 positive animals; all 3 of these animals had received antimicrobial agents during the year. These observations demonstrate that the epizootiology of H. pylori infection in rhesus monkeys may serve as a model for human infection.

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Selected References

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