Abstract
An immunoglobulin M (IgM) capture enzyme immunoassay was used to detect major overlapping outbreaks of disease in South Australia caused by coxsackieviruses B5 (CBV-5) and B6 (CBV-6). CBV-5-specific IgM was detected in patients presenting in spring 1992 with acute febrile illnesses, rash, severe acute respiratory disease, meningitis, myocarditis and/or pericarditis, while tests for other viruses were negative. CBV-5 was isolated from an early case. In December 1992 it was noted that CBV-6 had replaced CBV-5 as the major cause of disease. The CBV-6 epidemic continued until April 1993. Serum samples from 495 patients (276 inpatients) were submitted for testing. CBV-6 infection was associated with lower respiratory tract infection and persistent cough. This study demonstrated success of the IgM enzyme immunoassay and the need for diagnostic virology laboratories to look for CBV-6 infection in addition to the other five CBVs.
Full Text
The Full Text of this article is available as a PDF (192.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bell E. J., McCartney R. A., Basquill D., Chaudhuri A. K. Mu-antibody capture ELISA for the rapid diagnosis of enterovirus infections in patients with aseptic meningitis. J Med Virol. 1986 Jul;19(3):213–217. doi: 10.1002/jmv.1890190303. [DOI] [PubMed] [Google Scholar]
- Chonmaitree T., Menegus M. A., Powell K. R. The clinical relevance of 'CSF viral culture'. A two-year experience with aseptic meningitis in Rochester, NY. JAMA. 1982 Apr 2;247(13):1843–1847. [PubMed] [Google Scholar]
- Grist N. R., Bell E. J., Assaad F. Enteroviruses in human disease. Prog Med Virol. 1978;24:114–157. [PubMed] [Google Scholar]
- King M. L., Shaikh A., Bidwell D., Voller A., Banatvala J. E. Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset; type I) diabetes mellitus. Lancet. 1983 Jun 25;1(8339):1397–1399. doi: 10.1016/s0140-6736(83)92353-x. [DOI] [PubMed] [Google Scholar]
- Moore M., Kaplan M. H., McPhee J., Bregman D. J., Klein S. W. Epidemiologic, clinical, and laboratory features of Coxsackie B1-B5 infections in the United States, 1970-79. Public Health Rep. 1984 Sep-Oct;99(5):515–522. [PMC free article] [PubMed] [Google Scholar]
- Morens D. M., Zweighaft R. M., Bryan J. M. Non-polio enterovirus disease in the United States, 1971--1975. Int J Epidemiol. 1979 Mar;8(1):49–54. doi: 10.1093/ije/8.1.49. [DOI] [PubMed] [Google Scholar]
- Strikas R. A., Anderson L. J., Parker R. A. Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. J Infect Dis. 1986 Feb;153(2):346–351. doi: 10.1093/infdis/153.2.346. [DOI] [PubMed] [Google Scholar]
- Swanink C. M., Veenstra L., Poort Y. A., Kaan J. A., Galama J. M. Coxsackievirus B1-based antibody-capture enzyme-linked immunosorbent assay for detection of immunoglobulin G (IgG), IgM, and IgA with broad specificity for enteroviruses. J Clin Microbiol. 1993 Dec;31(12):3240–3246. doi: 10.1128/jcm.31.12.3240-3246.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]