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. 1995 Jul;33(7):1784–1786. doi: 10.1128/jcm.33.7.1784-1786.1995

Neisseria meningitidis with decreased susceptibility to penicillin in Saskatchewan, Canada.

J M Blondeau 1, F E Ashton 1, M Isaacson 1, Y Yaschuck 1, C Anderson 1, G Ducasse 1
PMCID: PMC228269  PMID: 7665646

Abstract

Moderately penicillin-resistant Neisseria meningitidis is rare in North America. We report an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada, with serogroup C N. meningitidis. The MICs of penicillin ranged from 0.12 to 0.25 micrograms/ml, and all isolates showing decreased susceptibility had identical genomic fingerprints when they were compared by pulsed-field gel electrophoresis. Our data indicate that N. meningitidis that is moderately resistant to penicillin is prevalent in Saskatchewan, Canada.

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Selected References

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  1. Ashton F. E., Ryan J. A., Borczyk A., Caugant D. A., Mancino L., Huang D. Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada. J Clin Microbiol. 1991 Nov;29(11):2489–2493. doi: 10.1128/jcm.29.11.2489-2493.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Caugant D. A., Zollinger W. D., Mocca L. F., Frasch C. E., Whittam T. S., Frøholm L. O., Selander R. K. Genetic relationships and clonal population structure of serotype 2 strains of Neisseria meningitidis. Infect Immun. 1987 Jun;55(6):1503–1512. doi: 10.1128/iai.55.6.1503-1512.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dorobă O., Leveneţ I., Paşolescu O., Lăzăroae D. Characteristics of Neisseria meningitidis strains isolated in Romania between 1986 and 1989. Arch Roum Pathol Exp Microbiol. 1990 Jul-Sep;49(3):215–221. [PubMed] [Google Scholar]
  4. Heimann G. A., Mikel D. E., Naus M., Goel V., Tischler M., Carlson J. A., Schabas R., Pasut G., Borczyk A., Krishnan C. Meningococcal disease in Ontario during the winter of 1988-1989. Can Dis Wkly Rep. 1989 Mar 18;15(11):59–62. [PubMed] [Google Scholar]
  5. Hughes J. H., Biedenbach D. J., Erwin M. E., Jones R. N. E test as susceptibility test and epidemiologic tool for evaluation of Neisseria meningitidis isolates. J Clin Microbiol. 1993 Dec;31(12):3255–3259. doi: 10.1128/jcm.31.12.3255-3259.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jackson L. A., Tenover F. C., Baker C., Plikaytis B. D., Reeves M. W., Stocker S. A., Weaver R. E., Wenger J. D. Prevalence of Neisseria meningitidis relatively resistant to penicillin in the United States, 1991. Meningococcal Disease Study Group. J Infect Dis. 1994 Feb;169(2):438–441. doi: 10.1093/infdis/169.2.438. [DOI] [PubMed] [Google Scholar]
  7. Jones D. M., Sutcliffe E. M. Meningococci with reduced susceptibility to penicillin. Lancet. 1990 Apr 7;335(8693):863–864. doi: 10.1016/0140-6736(90)90985-e. [DOI] [PubMed] [Google Scholar]
  8. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mendelman P. M., Campos J., Chaffin D. O., Serfass D. A., Smith A. L., Sáez-Nieto J. A. Relative penicillin G resistance in Neisseria meningitidis and reduced affinity of penicillin-binding protein 3. Antimicrob Agents Chemother. 1988 May;32(5):706–709. doi: 10.1128/aac.32.5.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Riley G., Brown S., Krishnan C. Penicillin resistance in Neisseria meningitidis. N Engl J Med. 1991 Apr 4;324(14):997–997. doi: 10.1056/NEJM199104043241416. [DOI] [PubMed] [Google Scholar]
  11. Selander R. K., Caugant D. A., Ochman H., Musser J. M., Gilmour M. N., Whittam T. S. Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol. 1986 May;51(5):873–884. doi: 10.1128/aem.51.5.873-884.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Strathdee C. A., Tyler S. D., Ryan J. A., Johnson W. M., Ashton F. E. Genomic fingerprinting of Neisseria meningitidis associated with group C meningococcal disease in Canada. J Clin Microbiol. 1993 Sep;31(9):2506–2508. doi: 10.1128/jcm.31.9.2506-2508.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sutcliffe E. M., Jones D. M., el-Sheikh S., Percival A. Penicillin-insensitive meningococci in the UK. Lancet. 1988 Mar 19;1(8586):657–658. doi: 10.1016/s0140-6736(88)91469-9. [DOI] [PubMed] [Google Scholar]
  14. Sáez-Nieto J. A., Fontanals D., Garcia de Jalon J., Martinez de Artola V., Peña P., Morera M. A., Verdaguer R., Sanfeliu I., Belio-Blasco C., Perez-Saenz J. L. Isolation of Neisseria meningitidis strains with increase of penicillin minimal inhibitory concentrations. Epidemiol Infect. 1987 Oct;99(2):463–469. doi: 10.1017/s0950268800067960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sáez-Nieto J. A., Lujan R., Berrón S., Campos J., Viñas M., Fusté C., Vazquez J. A., Zhang Q. Y., Bowler L. D., Martinez-Suarez J. V. Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985-1989). Clin Infect Dis. 1992 Feb;14(2):394–402. doi: 10.1093/clinids/14.2.394. [DOI] [PubMed] [Google Scholar]
  16. Taylor D. E., Eaton M., Yan W., Chang N. Genome maps of Campylobacter jejuni and Campylobacter coli. J Bacteriol. 1992 Apr;174(7):2332–2337. doi: 10.1128/jb.174.7.2332-2337.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Uriz S., Pineda V., Grau M., Nava J. M., Bella F., Morera M. A., Fontanals D., Font B., Martí C., Deulofeu F. Neisseria meningitidis with reduced sensitivity to penicillin: observations in 10 children. Scand J Infect Dis. 1991;23(2):171–174. doi: 10.3109/00365549109023396. [DOI] [PubMed] [Google Scholar]

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