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. 1995 Jul;33(7):1968–1970. doi: 10.1128/jcm.33.7.1968-1970.1995

Human herpesviruses 6 and 7 in cervixes of pregnant women.

T Okuno 1, H Oishi 1, K Hayashi 1, M Nonogaki 1, K Tanaka 1, K Yamanishi 1
PMCID: PMC228316  PMID: 7665687

Abstract

We looked for human herpesvirus 6 (HHV-6) and HHV-7 genomes in the cervixes of pregnant women in the late stages of their pregnancies. Of 72 samples collected with cervical swabs and amplified by nested PCR, we found that 14 (19.4%) and 2 (2.7%) contained detectable HHV-6 and HHV-7 genomes, respectively. The two samples in which HHV-7 DNA was detected also contained HHV-6 genomes. Hybridization of HHV-6 DNA amplified by PCR with variant-specific probes revealed that all of these DNA samples belonged to variant type B. These results indicated that HHV-6 and/or HHV-7 exists in the cervixes of infected women in late pregnancy and may cause perinatal infection.

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Selected References

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  1. Ando Y., Kakimoto K., Ekuni Y., Ichijo M. HHV-6 infection during pregnancy and spontaneous abortion. Lancet. 1992 Nov 21;340(8830):1289–1289. doi: 10.1016/0140-6736(92)92990-w. [DOI] [PubMed] [Google Scholar]
  2. Aubin J. T., Poirel L., Agut H., Huraux J. M., Bignozzi C., Brossard Y., Mulliez N., Roume J., Lecuru F., Taurelle R. Intrauterine transmission of human herpesvirus 6. Lancet. 1992 Aug 22;340(8817):482–483. doi: 10.1016/0140-6736(92)91801-e. [DOI] [PubMed] [Google Scholar]
  3. Dunne W. M., Jr, Demmler G. J. Serological evidence for congenital transmission of human herpesvirus 6. Lancet. 1992 Jul 11;340(8811):121–122. [PubMed] [Google Scholar]
  4. Frenkel N., Schirmer E. C., Wyatt L. S., Katsafanas G., Roffman E., Danovich R. M., June C. H. Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci U S A. 1990 Jan;87(2):748–752. doi: 10.1073/pnas.87.2.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Human herpesvirus-6 strain groups: a nomenclature. Arch Virol. 1993;129(1-4):363–366. doi: 10.1007/BF01316913. [DOI] [PubMed] [Google Scholar]
  6. Leach C. T., Newton E. R., McParlin S., Jenson H. B. Human herpesvirus 6 infection of the female genital tract. J Infect Dis. 1994 Jun;169(6):1281–1283. doi: 10.1093/infdis/169.6.1281. [DOI] [PubMed] [Google Scholar]
  7. Levy J. A., Ferro F., Greenspan D., Lennette E. T. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet. 1990 May 5;335(8697):1047–1050. doi: 10.1016/0140-6736(90)92628-u. [DOI] [PubMed] [Google Scholar]
  8. Martin M. E., Nicholas J., Thomson B. J., Newman C., Honess R. W. Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. J Virol. 1991 Oct;65(10):5381–5390. doi: 10.1128/jvi.65.10.5381-5390.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Okuno T., Mukai T., Baba K., Ohsumi Y., Takahashi M., Yamanishi K. Outbreak of exanthem subitum in an orphanage. J Pediatr. 1991 Nov;119(5):759–761. doi: 10.1016/s0022-3476(05)80294-x. [DOI] [PubMed] [Google Scholar]
  10. Okuno T., Takahashi K., Balachandra K., Shiraki K., Yamanishi K., Takahashi M., Baba K. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol. 1989 Apr;27(4):651–653. doi: 10.1128/jcm.27.4.651-653.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  12. Tanaka K., Kondo T., Torigoe S., Okada S., Mukai T., Yamanishi K. Human herpesvirus 7: another causal agent for roseola (exanthem subitum). J Pediatr. 1994 Jul;125(1):1–5. doi: 10.1016/s0022-3476(94)70113-x. [DOI] [PubMed] [Google Scholar]
  13. Wiersbitzky S., Beyersdorf E., Burtzlaff C., Wiersbitzky H., Crusius S., Weinke I. Pre- and perinatal infections due to human herpesvirus-6 and Epstein-Barr-virus with lethal outcome or severe residual encephalopathy. Padiatr Grenzgeb. 1993;31(4):199–201. [PubMed] [Google Scholar]
  14. Wyatt L. S., Rodriguez W. J., Balachandran N., Frenkel N. Human herpesvirus 7: antigenic properties and prevalence in children and adults. J Virol. 1991 Nov;65(11):6260–6265. doi: 10.1128/jvi.65.11.6260-6265.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Yalcin S., Karpuzoglu T., Suleymanlar G., Mutlu G., Mukai T., Yamamoto T., Isegawa Y., Yamanishi K. Human herpesvirus 6 and human herpesvirus 7 infections in renal transplant recipients and healthy adults in Turkey. Arch Virol. 1994;136(1-2):183–190. doi: 10.1007/BF01538827. [DOI] [PubMed] [Google Scholar]
  16. Yamamoto T., Mukai T., Kondo K., Yamanishi K. Variation of DNA sequence in immediate-early gene of human herpesvirus 6 and variant identification by PCR. J Clin Microbiol. 1994 Feb;32(2):473–476. doi: 10.1128/jcm.32.2.473-476.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. doi: 10.1016/s0140-6736(88)91893-4. [DOI] [PubMed] [Google Scholar]

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