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. 1995 Aug;33(8):2002–2006. doi: 10.1128/jcm.33.8.2002-2006.1995

Human Bordetella bronchiseptica infection related to contact with infected animals: persistence of bacteria in host.

P Gueirard 1, C Weber 1, A Le Coustumier 1, N Guiso 1
PMCID: PMC228324  PMID: 7559937

Abstract

Within a period of 2 1/2 years, Bordetella bronchiseptica was isolated four times from a 79-year-old woman with bronchopneumonia. We have demonstrated by pulsed-field gel electrophoresis that this infection was related to contact with infected rabbits. The initial human B. bronchiseptica isolate had a phenotype characteristic of usual B. bronchiseptica clinical isolates; it produced toxin and adhesins, such as adenylate cyclase-hemolysin, filamentous hemagglutinin, and pertactin, and was able to induce lethality in a murine respiratory model. By contrast, although the three successive human isolates produced adhesins, they did not express adenylate cyclase-hemolysin and were unable to induce lethality. This implies that adenylate cyclase-hemolysin is required to induce lethality. We suggest that B. bronchiseptica may persist in the host, with expression of adenylate cyclase-hemolysin being essential for the initiation of infection and expression of adhesins being essential for persistence.

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Selected References

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