Abstract
Platelia-Toxo IgA and IMx Toxo IgA assays were used with 260 serum samples, of which 93 were from seroconverted patients, 58 were from 21 congenitally infected children, and 109 were from uninfected patients, to detect anti-P30 immunoglobulin A antibodies. Because of its enhanced sensitivity, Platelia-Toxo IgA is more efficient in diagnosing acute or congenital toxoplasmosis. IMx Toxo IgA must not be used to diagnose congenital toxoplasmosis.
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- Bessières M. H., Roques C., Berrebi A., Barre V., Cazaux M., Séguéla J. P. IgA antibody response during acquired and congenital toxoplasmosis. J Clin Pathol. 1992 Jul;45(7):605–608. doi: 10.1136/jcp.45.7.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Decoster A., Darcy F., Caron A., Capron A. IgA antibodies against P30 as markers of congenital and acute toxoplasmosis. Lancet. 1988 Nov 12;2(8620):1104–1107. doi: 10.1016/s0140-6736(88)90523-5. [DOI] [PubMed] [Google Scholar]
- Decoster A., Darcy F., Caron A., Vinatier D., Houze de L'Aulnoit D., Vittu G., Niel G., Heyer F., Lecolier B., Delcroix M. Anti-P30 IgA antibodies as prenatal markers of congenital toxoplasma infection. Clin Exp Immunol. 1992 Feb;87(2):310–315. doi: 10.1111/j.1365-2249.1992.tb02993.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Decoster A., Slizewicz B., Simon J., Bazin C., Darcy F., Vittu G., Boulanger C., Champeau Y., Demory J. L., Duhamel M. Platelia-Toxo IgA, a new kit for early diagnosis of congenital toxoplasmosis by detection of anti-P30 immunoglobulin A antibodies. J Clin Microbiol. 1991 Oct;29(10):2291–2295. doi: 10.1128/jcm.29.10.2291-2295.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gross U., Roos T., Appoldt D., Heesemann J. Improved serological diagnosis of Toxoplasma gondii infection by detection of immunoglobulin A (IgA) and IgM antibodies against P30 by using the immunoblot technique. J Clin Microbiol. 1992 Jun;30(6):1436–1441. doi: 10.1128/jcm.30.6.1436-1441.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huskinson J., Thulliez P., Remington J. S. Toxoplasma antigens recognized by human immunoglobulin A antibodies. J Clin Microbiol. 1990 Dec;28(12):2632–2636. doi: 10.1128/jcm.28.12.2632-2636.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson A. M. The antigenic structure of Toxoplasma gondii: a review. Pathology. 1985 Jan;17(1):9–19. doi: 10.3109/00313028509063716. [DOI] [PubMed] [Google Scholar]
- Le Fichoux Y., Marty P., Chan H. Les IgA sériques spécifiques dans le diagnostic de la toxoplasmose. Ann Pediatr (Paris) 1987 May;34(5):375–379. [PubMed] [Google Scholar]
- Partanen P., Turunen H. J., Paasivuo R. T., Leinikki P. O. Immunoblot analysis of Toxoplasma gondii antigens by human immunoglobulins G, M, and A antibodies at different stages of infection. J Clin Microbiol. 1984 Jul;20(1):133–135. doi: 10.1128/jcm.20.1.133-135.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Patel B., Young Y., Duffy K., Tanner R. P., Johnson J., Holliman R. E. Immunoglobulin-A detection and the investigation of clinical toxoplasmosis. J Med Microbiol. 1993 Apr;38(4):286–292. doi: 10.1099/00222615-38-4-286. [DOI] [PubMed] [Google Scholar]
- Pinon J. M., Thoannes H., Pouletty P. H., Poirriez J., Damiens J., Pelletier P. Detection of IgA specific for toxoplasmosis in serum and cerebrospinal fluid using a non-enzymatic IgA-capture assay. Diagn Immunol. 1986;4(5):223–227. [PubMed] [Google Scholar]
- Potasman I., Araujo F. G., Thulliez P., Desmonts G., Remington J. S. Toxoplasma gondii antigens recognized by sequential samples of serum obtained from congenitally infected infants. J Clin Microbiol. 1987 Oct;25(10):1926–1931. doi: 10.1128/jcm.25.10.1926-1931.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Santoro F., Afchain D., Pierce R., Cesbron J. Y., Ovlaque G., Capron A. Serodiagnosis of toxoplasma infection using a purified parasite protein (P30). Clin Exp Immunol. 1985 Nov;62(2):262–269. [PMC free article] [PubMed] [Google Scholar]
- Sharma S. D., Mullenax J., Araujo F. G., Erlich H. A., Remington J. S. Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J Immunol. 1983 Aug;131(2):977–983. [PubMed] [Google Scholar]
- Stepick-Biek P., Thulliez P., Araujo F. G., Remington J. S. IgA antibodies for diagnosis of acute congenital and acquired toxoplasmosis. J Infect Dis. 1990 Jul;162(1):270–273. doi: 10.1093/infdis/162.1.270. [DOI] [PubMed] [Google Scholar]
- van Loon A. M., van der Logt J. T., Heessen F. W., van der Veen J. Enzyme-linked immunosorbent assay that uses labeled antigen for detection of immunoglobulin M and A antibodies in toxoplasmosis: comparison with indirect immunofluorescence and double-sandwich enzyme-linked immunosorbent assay. J Clin Microbiol. 1983 Jun;17(6):997–1004. doi: 10.1128/jcm.17.6.997-1004.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]