Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1995 Sep;33(9):2435–2444. doi: 10.1128/jcm.33.9.2435-2444.1995

Comparison of MICs of ceftiofur and other antimicrobial agents against bacterial pathogens of swine from the United States, Canada, and Denmark.

S A Salmon 1, J L Watts 1, C A Case 1, L J Hoffman 1, H C Wegener 1, R J Yancey Jr 1
PMCID: PMC228432  PMID: 7494042

Abstract

The MICs of ceftiofur and other antimicrobial agents, tested for comparison, for 515 bacterial isolates of pigs from the United States, Canada, and Denmark with various diseases were compared. The organisms tested included Actinobacillus pleuropneumoniae, Escherichia coli, Pasteurella multocida, Salmonella choleraesuis, Salmonella typhimurium, Streptococcus suis, Streptococcus dysgalactiae subsp. equisimilis, Streptococcus equi subsp. equi, and Streptococcus equi subsp. zooepidemicus. In addition to ceftiofur, the following antimicrobial agents or combinations were tested: enrofloxacin, ampicillin, sulfamethazine, trimethoprim-sulfadiazine (1:19), erythromycin, lincomycin, spectinomycin, lincomycin-spectinomycin (1:8), tilmicosin, and tetracycline. Tilmicosin was only tested against the U.S. isolates. Overall, ceftiofur and enrofloxacin were the most active antimicrobial agents tested against all isolates, with MICs inhibiting 90% of isolates tested (MIC90s) of < or = 2.0 and < or = 1.0 microgram/ml, respectively. Erythromycin, sulfamethazine, spectinomycin, and lincomycin demonstrated limited activity against all of the organisms tested, with MIC90s of > or = 8.0, > or = 256.0, > or = 32.0, and > or = 16.0 micrograms/ml, respectively. Trimethoprim-sulfadiazine was active against isolates of A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s, < or = 0.5 microgram/ml) but was less active against the E. coli strains tested (MIC90, > 16.0 micrograms/ml). Ampicillin was active against the P. multocida, S. suis, and S. equi isolates tested (MIC90s, 0.5, 0.06, and 0.06 micrograms/ml, respectively) and was moderately active against S. typhimurium (MIC90s, 2.0 micrograms/ml). However, this antimicrobial agent was much less active when it was tested against A. pleuropneumoniae, S. cholerae-suis, and E. coli (MIC90s, 16.0, > 32.0, and 32.0 micrograms/ml, respectively). Against the U.S. isolates of A. pleuropneumoniae and P. multocida, tilmicosin was moderately active (MIC90s, 4.0 and 8.0 micrograms/ml, respectively). However, this compound was not active against the remaining U.S. isolates (MIC90s, > 64.0 micrograms/ml). Differences in the MICs from one country to another were not detected with enrofloxacin, ceftiofur, or lincomycin for the strains tested, but variations in the MICs of the remaining antimicrobial agents were observed.

Full Text

The Full Text of this article is available as a PDF (319.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eaves L. E., Blackall P. J., Fegan M. Characterisation and antimicrobial sensitivity of haemophili isolated from pigs. Aust Vet J. 1989 Jan;66(1):1–4. doi: 10.1111/j.1751-0813.1989.tb09701.x. [DOI] [PubMed] [Google Scholar]
  2. Fales W. H., Morehouse L. G., Mittal K. R., Bean-Knudsen C., Nelson S. L., Kintner L. D., Turk J. R., Turk M. A., Brown T. P., Shaw D. P. Antimicrobial susceptibility and serotypes of Actinobacillus (Haemophilus) pleuropneumoniae recovered from Missouri swine. J Vet Diagn Invest. 1989 Jan;1(1):16–19. doi: 10.1177/104063878900100106. [DOI] [PubMed] [Google Scholar]
  3. Fales W. H., Turk J. R., Miller M. A., Bean-Knudsen C., Nelson S. L., Morehouse L. G., Gosser H. S. Antimicrobial susceptibility of Pasteurella multocida type D from Missouri swine. J Vet Diagn Invest. 1990 Jan;2(1):80–81. doi: 10.1177/104063879000200118. [DOI] [PubMed] [Google Scholar]
  4. Gilbride K. A., Rosendal S. Antimicrobial susceptibility of 51 strains of Haemophilus pleuropneumoniae. Can J Comp Med. 1984 Jan;48(1):47–50. [PMC free article] [PubMed] [Google Scholar]
  5. Gutiérrez C. B., Píriz S., Vadillo S., Rodríguez Ferri E. F. In vitro susceptibility of Actinobacillus pleuropneumoniae strains to 42 antimicrobial agents. Am J Vet Res. 1993 Apr;54(4):546–550. [PubMed] [Google Scholar]
  6. Hannan P. C., O'Hanlon P. J., Rogers N. H. In vitro evaluation of various quinolone antibacterial agents against veterinary mycoplasmas and porcine respiratory bacterial pathogens. Res Vet Sci. 1989 Mar;46(2):202–211. [PubMed] [Google Scholar]
  7. Hommez J., Devriese L. A., Castryck F., Miry C. Bèta-hemolytic streptococci from pigs: bacteriological diagnosis. Zentralbl Veterinarmed B. 1991 Aug;38(6):441–444. doi: 10.1111/j.1439-0450.1991.tb00893.x. [DOI] [PubMed] [Google Scholar]
  8. Nielsen R. Seroepidemiology of Actinobacillus pleuropneumoniae. Can Vet J. 1988 Jul;29(7):580–582. [PMC free article] [PubMed] [Google Scholar]
  9. Ose E. E. In vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic. J Antibiot (Tokyo) 1987 Feb;40(2):190–194. doi: 10.7164/antibiotics.40.190. [DOI] [PubMed] [Google Scholar]
  10. Raemdonck D. L., Tanner A. C., Tolling S. T., Michener S. L. Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida and Salmonella choleraesuis isolates from pigs. Vet Rec. 1994 Jan 1;134(1):5–7. doi: 10.1136/vr.134.1.5. [DOI] [PubMed] [Google Scholar]
  11. Reams R. Y., Glickman L. T., Harrington D. D., Bowersock T. L., Thacker H. L. Streptococcus suis infection in swine: a retrospective study of 256 cases. Part I. Epidemiologic factors and antibiotic susceptibility patterns. J Vet Diagn Invest. 1993 Jul;5(3):363–367. doi: 10.1177/104063879300500310. [DOI] [PubMed] [Google Scholar]
  12. Smith I. M., Mackie A., Lida J. Effect of giving enrofloxacin in the diet to pigs experimentally infected with Actinobacillus pleuropneumoniae. Vet Rec. 1991 Jul 13;129(2):25–29. doi: 10.1136/vr.129.2.25. [DOI] [PubMed] [Google Scholar]
  13. Touil F., Higgins R., Nadeau M. Isolation of Streptococcus suis from diseased pigs in Canada. Vet Microbiol. 1988 Jun;17(2):171–177. doi: 10.1016/0378-1135(88)90008-9. [DOI] [PubMed] [Google Scholar]
  14. Turgeon P. L., Higgins R., Gottschalk M., Beaudoin M. Antimicrobial susceptibility of Streptococcus suis isolates. Br Vet J. 1994 May-Jun;150(3):263–269. doi: 10.1016/S0007-1935(05)80006-5. [DOI] [PubMed] [Google Scholar]
  15. Turk J. R., Fales W. H., Maddox C., Miller M., Pace L., Fischer J., Kreeger J., Johnson G., Turnquist S., Ramos J. A. Pneumonia associated with Salmonella choleraesuis infection in swine: 99 cases (1987-1990). J Am Vet Med Assoc. 1992 Nov 15;201(10):1615–1616. [PubMed] [Google Scholar]
  16. Watts J. L., Yancey R. J., Jr, Salmon S. A., Case C. A. A 4-year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America. J Clin Microbiol. 1994 Mar;32(3):725–731. doi: 10.1128/jcm.32.3.725-731.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wegener H. C., Watts J. L., Salmon S. A., Yancey R. J., Jr Antimicrobial susceptibility of Staphylococcus hyicus isolated from exudative epidermitis in pigs. J Clin Microbiol. 1994 Mar;32(3):793–795. doi: 10.1128/jcm.32.3.793-795.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wilson M. R., Takov R., Friendship R. M., Martin S. W., McMillan I., Hacker R. R., Swaminathan S. Prevalence of respiratory diseases and their association with growth rate and space in randomly selected swine herds. Can J Vet Res. 1986 Apr;50(2):209–216. [PMC free article] [PubMed] [Google Scholar]
  19. Wray C., Beedell Y. E., McLaren I. M. A survey of antimicrobial resistance in Salmonellae isolated from animals in England and Wales during 1984-1987. Br Vet J. 1991 Jul-Aug;147(4):356–369. doi: 10.1016/0007-1935(91)90009-C. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES