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. 1995 Sep;33(9):2485–2488. doi: 10.1128/jcm.33.9.2485-2488.1995

Detection of measles virus RNA in urine specimens from vaccine recipients.

P A Rota 1, A S Khan 1, E Durigon 1, T Yuran 1, Y S Villamarzo 1, W J Bellini 1
PMCID: PMC228449  PMID: 7494055

Abstract

Analysis of urine specimens by using reverse transcriptase-PCR was evaluated as a rapid assay to identify individuals infected with measles virus. For the study, daily urine samples were obtained from either 15-month-old children or young adults following measles immunization. Overall, measles virus RNA was detected in 10 of 12 children during the 2-week sampling period. In some cases, measles virus RNA was detected as early as 1 day or as late as 14 days after vaccination. Measles virus RNA was also detected in the urine samples from all four of the young adults between 1 and 13 days after vaccination. This assay will enable continued studies of the shedding and transmission of measles virus and, it is hoped, will provide a rapid means to identify measles infection, especially in mild or asymptomatic cases.

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Selected References

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