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. 1996 Feb;34(2):338–341. doi: 10.1128/jcm.34.2.338-341.1996

Distribution of capsular types and antibiotic susceptibility of invasive Streptococcus pneumoniae isolated from aborigines in central Australia.

M Gratten 1, P Torzillo 1, F Morey 1, J Dixon 1, J Erlich 1, J Hagger 1, J Henrichsen 1
PMCID: PMC228793  PMID: 8789011

Abstract

Streptococcus pneumoniae strains isolated from 203 episodes of invasive disease in central Australian Aborigines were studied. Capsular types from children aged 0 to 4 years (n = 89) belonged most commonly to types 14, 6B, 9V, 4, 18C, and 19F, which together accounted for 67% of the pediatric strains. In adults (n = 98), types 1, 7F, 3, 4, 12F, and 8 contributed 68% of the isolates. Of 114 pneumococci from patients 5 years and older, 102 (89.5%) were types represented in the 23-valent pneumococcal polysaccharide vaccine. The MICs of five antibiotics were determined for 201 strains by using the E-Test (AB Biodisk). No chloramphenicol or ceftriaxone resistance was found, but 46 strains (22.9%) showed diminished susceptibility to one or more of the drugs penicillin, erythromycin, and trimethoprim-sulfamethoxazole. Penicillin resistance occurred in 15.4% of all isolates tested but only within the intermediate range (0.1 to 1.0 microgram/ml). Resistance to trimethoprimsulfamethoxazole affected 13.9% of the pneumococci tested. All type 23F and most type 19F organisms were resistant to one or more antibiotics. Resistance was significantly more common in pediatric isolates than in those from adults (chi 2(1) = 14.1; P < 0.001).

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Selected References

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  1. Appelbaum P. C. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis. 1992 Jul;15(1):77–83. doi: 10.1093/clinids/15.1.77. [DOI] [PubMed] [Google Scholar]
  2. Austrian R. Pneumococcal polysaccharide vaccines. Rev Infect Dis. 1989 May-Jun;11 (Suppl 3):S598–S602. doi: 10.1093/clinids/11.supplement_3.s598. [DOI] [PubMed] [Google Scholar]
  3. Berman S. Epidemiology of acute respiratory infections in children of developing countries. Rev Infect Dis. 1991 May-Jun;13 (Suppl 6):S454–S462. doi: 10.1093/clinids/13.supplement_6.s454. [DOI] [PubMed] [Google Scholar]
  4. Breiman R. F., Butler J. C., Tenover F. C., Elliott J. A., Facklam R. R. Emergence of drug-resistant pneumococcal infections in the United States. JAMA. 1994 Jun 15;271(23):1831–1835. [PubMed] [Google Scholar]
  5. Broome C. V., Facklam R. R. Epidemiology of clinically significant isolates of Streptococcus pneumoniae in the United States. Rev Infect Dis. 1981 Mar-Apr;3(2):277–281. doi: 10.1093/clinids/3.2.277. [DOI] [PubMed] [Google Scholar]
  6. Collignon P. J., Bell J. M. Streptococcus pneumoniae: how common is penicillin resistance in Australia? Aust N Z J Med. 1992 Oct;22(5):473–476. [PubMed] [Google Scholar]
  7. Douglas R. M., Paton J. C., Duncan S. J., Hansman D. J. Antibody response to pneumococcal vaccination in children younger than five years of age. J Infect Dis. 1983 Jul;148(1):131–137. doi: 10.1093/infdis/148.1.131. [DOI] [PubMed] [Google Scholar]
  8. Dowson C. G., Hutchison A., Brannigan J. A., George R. C., Hansman D., Liñares J., Tomasz A., Smith J. M., Spratt B. G. Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8842–8846. doi: 10.1073/pnas.86.22.8842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gratten M., Manning K., Dixon J., Morey F., Torzillo P., Hanna J., Erlich J., Asche V., Riley I. Upper airway carriage by Haemophilus influenzae and Streptococcus pneumoniae in Australian aboriginal children hospitalised with acute lower respiratory infection. Southeast Asian J Trop Med Public Health. 1994 Mar;25(1):123–131. [PubMed] [Google Scholar]
  10. Gratten M., Montgomery J., Gerega G., Gratten H., Siwi H., Poli A., Koki G. Multiple colonization of the upper respiratory tract of Papua New Guinea children with Haemophilus influenzae and Streptococcus pneumoniae. Southeast Asian J Trop Med Public Health. 1989 Dec;20(4):501–509. [PubMed] [Google Scholar]
  11. Gratten M., Montgomery J. The bacteriology of acute pneumonia and meningitis in children in Papua New Guinea: assumptions, facts and technical strategies. P N G Med J. 1991 Sep;34(3):185–198. [PubMed] [Google Scholar]
  12. Henrichsen J. Six newly recognized types of Streptococcus pneumoniae. J Clin Microbiol. 1995 Oct;33(10):2759–2762. doi: 10.1128/jcm.33.10.2759-2762.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jacobs M. R., Koornhof H. J., Robins-Browne R. M., Stevenson C. M., Vermaak Z. A., Freiman I., Miller G. B., Witcomb M. A., Isaäcson M., Ward J. I. Emergence of multiply resistant pneumococci. N Engl J Med. 1978 Oct 5;299(14):735–740. doi: 10.1056/NEJM197810052991402. [DOI] [PubMed] [Google Scholar]
  14. Jetté L. P., Ringuette L., Dascal A., Lapointe J. R., Turgeon P. Pneumococcal resistance to antimicrobial agents in the province of Québec, Canada. J Clin Microbiol. 1994 Oct;32(10):2572–2575. doi: 10.1128/jcm.32.10.2572-2575.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Nielsen S. V., Henrichsen J. Capsular types of Streptococcus pneumoniae isolated from blood and CSF during 1982-1987. Clin Infect Dis. 1992 Nov;15(5):794–798. doi: 10.1093/clind/15.5.794. [DOI] [PubMed] [Google Scholar]
  16. Parkinson A. J., Davidson M., Fitzgerald M. A., Bulkow L. R., Parks D. J. Serotype distribution and antimicrobial resistance patterns of invasive isolates of Streptococcus pneumoniae: Alaska 1986-1990. J Infect Dis. 1994 Aug;170(2):461–464. doi: 10.1093/infdis/170.2.461. [DOI] [PubMed] [Google Scholar]
  17. Pedersen F. K., Henrichsen J. Detection of antibodies to pneumococcal capsular polysaccharides by enzyme-linked immunosorbent assay. J Clin Microbiol. 1982 Mar;15(3):372–378. doi: 10.1128/jcm.15.3.372-378.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pedersen F. K. Postsplenectomy infections in Danish children splenectomized 1969-1978. Acta Paediatr Scand. 1983 Jul;72(4):589–595. doi: 10.1111/j.1651-2227.1983.tb09776.x. [DOI] [PubMed] [Google Scholar]
  19. Pomat W. S., Lehmann D., Sanders R. C., Lewis D. J., Wilson J., Rogers S., Dyke T., Alpers M. P. Immunoglobulin G antibody responses to polyvalent pneumococcal vaccine in children in the highlands of Papua New Guinea. Infect Immun. 1994 May;62(5):1848–1853. doi: 10.1128/iai.62.5.1848-1853.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Robbins J. B., Austrian R., Lee C. J., Rastogi S. C., Schiffman G., Henrichsen J., Mäkelä P. H., Broome C. V., Facklam R. R., Tiesjema R. H. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis. 1983 Dec;148(6):1136–1159. doi: 10.1093/infdis/148.6.1136. [DOI] [PubMed] [Google Scholar]
  21. Robbins J. B., Lee C. J., Rastogi S. C., Schiffman G., Henrichsen J. Comparative immunogenicity of group 6 pneumococcal type 6A(6) and type 6B(26) capsular polysaccharides. Infect Immun. 1979 Dec;26(3):1116–1122. doi: 10.1128/iai.26.3.1116-1122.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Santosham M., Wolff M., Reid R., Hohenboken M., Bateman M., Goepp J., Cortese M., Sack D., Hill J., Newcomer W. The efficacy in Navajo infants of a conjugate vaccine consisting of Haemophilus influenzae type b polysaccharide and Neisseria meningitidis outer-membrane protein complex. N Engl J Med. 1991 Jun 20;324(25):1767–1772. doi: 10.1056/NEJM199106203242503. [DOI] [PubMed] [Google Scholar]
  23. Sessegolo J. F., Levin A. S., Levy C. E., Asensi M., Facklam R. R., Teixeira L. M. Distribution of serotypes and antimicrobial resistance of Streptococcus pneumoniae strains isolated in Brazil from 1988 to 1992. J Clin Microbiol. 1994 Apr;32(4):906–911. doi: 10.1128/jcm.32.4.906-911.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Steinhoff M. C. Developing and deploying pneumococcal and haemophilus vaccines. Lancet. 1993 Sep 11;342(8872):630–631. doi: 10.1016/0140-6736(93)91754-a. [DOI] [PubMed] [Google Scholar]
  25. Temple K., Greenwood B., Inskip H., Hall A., Koskela M., Leinonen M. Antibody response to pneumococcal capsular polysaccharide vaccine in African children. Pediatr Infect Dis J. 1991 May;10(5):386–390. doi: 10.1097/00006454-199105000-00008. [DOI] [PubMed] [Google Scholar]
  26. Torzillo P. J., Hanna J. N., Morey F., Gratten M., Dixon J., Erlich J. Invasive pneumococcal disease in central Australia. Med J Aust. 1995 Feb 20;162(4):182–186. doi: 10.5694/j.1326-5377.1995.tb126016a.x. [DOI] [PubMed] [Google Scholar]
  27. Trotman J., Hughes B., Mollison L. Invasive pneumococcal disease in central Australia. Clin Infect Dis. 1995 Jun;20(6):1553–1556. doi: 10.1093/clinids/20.6.1553. [DOI] [PubMed] [Google Scholar]

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