TABLE 1.
Neutralization of different HIV-1 isolates by sera from mice immunized with different gp120/mAb combinations
| % Neutralization of HIV-1 isolates | |||||
|---|---|---|---|---|---|
| LAI | JRFL | DJ263 | BX08 | SF162 | |
| Mice immunized with a | |||||
| gp120+1418 | <c | < | < | < | < |
| gp120+654D | 83 | 35 | 23 | < | 30 |
| gp120+559/64D | 90 | < | 21 | < | 29 |
| gp120+694/98D | 26 | 46 | 27 | 19 | < |
| PBS | < | < | < | < | < |
| MAbs to V3b | |||||
| 694/98D | NDd | 33 | < | ND | 82 |
| 447/52D | ND | < | < | ND | 71 |
a
All mouse sera were tested at 1:50 dilution
b
Anti-V3 mAbs were tested at 1μg/ml
c
Virus neutralization of <19%
d
Not done