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. 1993 Dec 2;123(6):1365–1371. doi: 10.1083/jcb.123.6.1365

Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi- derived COP-coated vesicles

PMCID: PMC2290881  PMID: 8253837

Abstract

The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.

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Selected References

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