Skip to main content
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1996 Aug;34(8):2014–2016. doi: 10.1128/jcm.34.8.2014-2016.1996

Efficacy of immunoglobulin M serodiagnostic test for rapid diagnosis of acute babesiosis.

P J Krause 1, R Ryan 1, S Telford 3rd 1, D Persing 1, A Spielman 1
PMCID: PMC229174  PMID: 8818902

Abstract

To evaluate the efficacy of an immunoglobulin M indirect immunofluorescent-antibody procedure for diagnosing acute babesiosis, we tested patients with acute babesiosis from a site in New England where the disease is enzootic. The sensitivity of the test was 91%, the specificity was 99%, the positive predictive value was 86%, and the negative predictive value was 99%. This B. microti immunoglobulin M indirect immunofluorescent-antibody procedure is sufficiently sensitive, specific, and reproducible for use in the routine clinical diagnosis of acute babesiosis.

Full Text

The Full Text of this article is available as a PDF (189.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dammin G. J., Spielman A., Benach J. L., Piesman J. The rising incidence of clinical Babesia microti infection. Hum Pathol. 1981 May;12(5):398–400. doi: 10.1016/s0046-8177(81)80020-2. [DOI] [PubMed] [Google Scholar]
  2. Krause P. J., Telford S. R., 3rd, Ryan R., Conrad P. A., Wilson M., Thomford J. W., Spielman A. Diagnosis of babesiosis: evaluation of a serologic test for the detection of Babesia microti antibody. J Infect Dis. 1994 Apr;169(4):923–926. doi: 10.1093/infdis/169.4.923. [DOI] [PubMed] [Google Scholar]
  3. Krause P. J., Telford S. R., 3rd, Ryan R., Hurta A. B., Kwasnik I., Luger S., Niederman J., Gerber M., Spielman A. Geographical and temporal distribution of babesial infection in Connecticut. J Clin Microbiol. 1991 Jan;29(1):1–4. doi: 10.1128/jcm.29.1.1-4.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Krause P. J., Telford S. R., 3rd, Spielman A., Sikand V., Ryan R., Christianson D., Burke G., Brassard P., Pollack R., Peck J. Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. JAMA. 1996 Jun 5;275(21):1657–1660. [PubMed] [Google Scholar]
  5. Mattia A. R., Waldron M. A., Sierra L. S. Use of the Quantitative Buffy Coat system for detection of parasitemia in patients with babesiosis. J Clin Microbiol. 1993 Oct;31(10):2816–2818. doi: 10.1128/jcm.31.10.2816-2818.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Meldrum S. C., Birkhead G. S., White D. J., Benach J. L., Morse D. L. Human babesiosis in New York State: an epidemiological description of 136 cases. Clin Infect Dis. 1992 Dec;15(6):1019–1023. doi: 10.1093/clind/15.6.1019. [DOI] [PubMed] [Google Scholar]
  7. Persing D. H., Herwaldt B. L., Glaser C., Lane R. S., Thomford J. W., Mathiesen D., Krause P. J., Phillip D. F., Conrad P. A. Infection with a babesia-like organism in northern California. N Engl J Med. 1995 Feb 2;332(5):298–303. doi: 10.1056/NEJM199502023320504. [DOI] [PubMed] [Google Scholar]
  8. Persing D. H., Mathiesen D., Marshall W. F., Telford S. R., Spielman A., Thomford J. W., Conrad P. A. Detection of Babesia microti by polymerase chain reaction. J Clin Microbiol. 1992 Aug;30(8):2097–2103. doi: 10.1128/jcm.30.8.2097-2103.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Steketee R. W., Eckman M. R., Burgess E. C., Kuritsky J. N., Dickerson J., Schell W. L., Godsey M. S., Jr, Davis J. P. Babesiosis in Wisconsin. A new focus of disease transmission. JAMA. 1985 May 10;253(18):2675–2678. doi: 10.1001/jama.253.18.2675. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES