Table 2.
IGF-1 protein levels (ng/ml) at birth and at age 7 or 8 years by genotypes of seven IGF1 tag-SNPs in a representative birth cohort
| Parameter | n | Genotype (%) | p value | ||
|---|---|---|---|---|---|
| rs35140968 | I/D (58) | I/I (35) | D/D (7) | ||
| At birth | 315 | 88.1 (2.8) | 91.1 (3.6) | 105.0 (8.9) | 0.179 |
| 7 or 8 years | 547 | 147.8 (2.9) | 147.3 (3.9) | 157.4 (9.1) | 0.581 |
| rs6214 | G/G (34) | G/A (50) | A/A (16) | ||
| At birth | 305 | 88.6 (3.6) | 87.7 (3.2) | 102.43 (5.30) | 0.048 |
| 7 or 8 years | 556 | 144.1 (4.0) | 148.9 (3.1) | 155.83 (5.70) | 0.239 |
| rs3730220 | A/A (38) | A/T (54) | T/T (9) | ||
| Birth | 299 | 94.1 (3.8) | 88.6 (2.9) | 89.6 (7.4) | 0.509 |
| 7 or 8 years | 548 | 152.0 (3.8) | 145.7 (3.0) | 141.8 (8.1) | 0.331 |
| rs6219 | G/G (84) | */A (16) | |||
| Birth | 300 | 91.0 (2.4) | 85.0 (5.7) | 0.329 | |
| 7 or 8 years | 547 | 150.1 (2.5) | 138.8 (5.8) | 0.072 | |
| rs2946831 | T/T (89) | */G (11) | |||
| Birth | 294 | 90.0 (2.3) | 95.2 (7.2) | 0.501 | |
| 7 or 8 years | 541 | 148.0 (2.4) | 153.9 (7.1) | 0.432 | |
| rs3730204 | T/T (97) | */C (3) | |||
| Birth | 294 | 111.3 (13.5) | 90.3 (2.3) | 0.126 | |
| 7 or 8 years | 548 | 173.8 (12.9) | 147.5 (2.3) | 0.046 | |
| rs12579108 | C/C (97) | */A (3) | |||
| Birth | 301 | 90.0 (2.2) | 101.4 (12.1) | 0.358 | |
| 7 or 8 years | 554 | 147.6 (2.3) | 176.8 (15.9) | 0.017 | |
Values are mean (SE) for IGF-1 concentration and per cent for genotype
*Additive models, adjusted for age and sex