Skip to main content
PMC home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1996 Sep;34(9):2320–2321. doi: 10.1128/jcm.34.9.2320-2321.1996

Detection of human herpesvirus 6 and human herpesvirus 7 in the submandibular gland, parotid gland, and lip salivary gland by PCR.

E Sada 1, M Yasukawa 1, C Ito 1, A Takeda 1, T Shiosaka 1, H Tanioka 1, S Fujita 1
PMCID: PMC229244  PMID: 8862611

Abstract

In order to define the major sites of persistence of human herpesvirus 6 (HHV-6) and HHV-7, PCR with DNAs from more than 100 specimens of 3 different salivary glands was performed. HHV-6 DNA was detected in 52 (88.1%) of 59 submandibular gland, 17 (63.0%) of 27 parotid gland, and 9 (52.9%) of 17 lip salivary gland specimens. On the other hand, HHV-7 DNA was detected in 59 (100%) of 59 submandibular gland, 23 (85.2%) of 27 parotid gland, and 10 (58.8%) of 17 lip salivary gland specimens. These findings demonstrate that salivary glands are a site of persistent infection of both HHV-6 and HHV-7 and that among the three types of salivary gland examined, the submandibular gland is the primary one in which these herpesviruses, especially HHV-7, persist.

Full Text

The Full Text of this article is available as a PDF (207.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berneman Z. N., Ablashi D. V., Li G., Eger-Fletcher M., Reitz M. S., Jr, Hung C. L., Brus I., Komaroff A. L., Gallo R. C. Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10552–10556. doi: 10.1073/pnas.89.21.10552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Black J. B., Inoue N., Kite-Powell K., Zaki S., Pellett P. E. Frequent isolation of human herpesvirus 7 from saliva. Virus Res. 1993 Jul;29(1):91–98. doi: 10.1016/0168-1702(93)90128-a. [DOI] [PubMed] [Google Scholar]
  3. Cone R. W., Huang M. L., Ashley R., Corey L. Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J Clin Microbiol. 1993 May;31(5):1262–1267. doi: 10.1128/jcm.31.5.1262-1267.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Di Luca D., Mirandola P., Ravaioli T., Dolcetti R., Frigatti A., Bovenzi P., Sighinolfi L., Monini P., Cassai E. Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol. 1995 Apr;45(4):462–468. doi: 10.1002/jmv.1890450418. [DOI] [PubMed] [Google Scholar]
  5. Fox J. D., Briggs M., Ward P. A., Tedder R. S. Human herpesvirus 6 in salivary glands. Lancet. 1990 Sep 8;336(8715):590–593. doi: 10.1016/0140-6736(90)93392-3. [DOI] [PubMed] [Google Scholar]
  6. Harnett G. B., Farr T. J., Pietroboni G. R., Bucens M. R. Frequent shedding of human herpesvirus 6 in saliva. J Med Virol. 1990 Feb;30(2):128–130. doi: 10.1002/jmv.1890300209. [DOI] [PubMed] [Google Scholar]
  7. Hidaka Y., Liu Y., Yamamoto M., Mori R., Miyazaki C., Kusuhara K., Okada K., Ueda K. Frequent isolation of human herpesvirus 7 from saliva samples. J Med Virol. 1993 Aug;40(4):343–346. doi: 10.1002/jmv.1890400416. [DOI] [PubMed] [Google Scholar]
  8. Kondo K., Nagafuji H., Hata A., Tomomori C., Yamanishi K. Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Infect Dis. 1993 May;167(5):1197–1200. doi: 10.1093/infdis/167.5.1197. [DOI] [PubMed] [Google Scholar]
  9. Krueger G. R., Wassermann K., De Clerck L. S., Stevens W. J., Bourgeois N., Ablashi D. V., Josephs S. F., Balachandran N. Latent herpesvirus-6 in salivary and bronchial glands. Lancet. 1990 Nov 17;336(8725):1255–1256. doi: 10.1016/0140-6736(90)92874-h. [DOI] [PubMed] [Google Scholar]
  10. Levy J. A., Ferro F., Greenspan D., Lennette E. T. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet. 1990 May 5;335(8697):1047–1050. doi: 10.1016/0140-6736(90)92628-u. [DOI] [PubMed] [Google Scholar]
  11. Wyatt L. S., Frenkel N. Human herpesvirus 7 is a constitutive inhabitant of adult human saliva. J Virol. 1992 May;66(5):3206–3209. doi: 10.1128/jvi.66.5.3206-3209.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wyatt L. S., Rodriguez W. J., Balachandran N., Frenkel N. Human herpesvirus 7: antigenic properties and prevalence in children and adults. J Virol. 1991 Nov;65(11):6260–6265. doi: 10.1128/jvi.65.11.6260-6265.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Yamanishi K. Human herpesvirus 6. Microbiol Immunol. 1992;36(6):551–561. doi: 10.1111/j.1348-0421.1992.tb02055.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES