Abstract
We report the activity of recombinant human lactoferrin against Helicobacter pylori. Lactoferrin exerted a time- and dose-dependent action against 8 of the 13 clinical isolates of H. pylori tested in vitro. These results highlight a potential therapeutic use for lactoferrin against H.pylori infection.
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- Arnold R. R., Brewer M., Gauthier J. J. Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms. Infect Immun. 1980 Jun;28(3):893–898. doi: 10.1128/iai.28.3.893-898.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bellamy W., Takase M., Yamauchi K., Wakabayashi H., Kawase K., Tomita M. Identification of the bactericidal domain of lactoferrin. Biochim Biophys Acta. 1992 May 22;1121(1-2):130–136. doi: 10.1016/0167-4838(92)90346-f. [DOI] [PubMed] [Google Scholar]
- Bullen J. J., Rogers H. J., Griffiths E. Role of iron in bacterial infection. Curr Top Microbiol Immunol. 1978;80:1–35. doi: 10.1007/978-3-642-66956-9_1. [DOI] [PubMed] [Google Scholar]
- Ellison R. T., 3rd, Giehl T. J., LaForce F. M. Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infect Immun. 1988 Nov;56(11):2774–2781. doi: 10.1128/iai.56.11.2774-2781.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maiuri L., Rossi M., Raia V., Paparo F., Garipoli V., Auricchio S. Surface staining on the villus of lactase protein and lactase activity in adult-type hypolactasia. Gastroenterology. 1993 Sep;105(3):708–714. doi: 10.1016/0016-5085(93)90887-i. [DOI] [PubMed] [Google Scholar]
- Masson P. L., Heremans J. F., Schonne E. Lactoferrin, an iron-binding protein in neutrophilic leukocytes. J Exp Med. 1969 Sep 1;130(3):643–658. doi: 10.1084/jem.130.3.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reiter B. The biological significance of lactoferrin. Int J Tissue React. 1983;5(1):87–96. [PubMed] [Google Scholar]
- Ward P. P., Piddington C. S., Cunningham G. A., Zhou X., Wyatt R. D., Conneely O. M. A system for production of commercial quantities of human lactoferrin: a broad spectrum natural antibiotic. Biotechnology (N Y) 1995 May;13(5):498–503. doi: 10.1038/nbt0595-498. [DOI] [PubMed] [Google Scholar]