Abstract
Cefotaxime- and ceftriaxone-resistant Streptococcus pneumoniae is now appearing in some medical centers, but 30-micrograms cefotaxime or 30-micrograms ceftriaxone disks are not reliable for detecting such strains. Studies were undertaken to select another cephalosporin disk that might be used as a screening test that could be used in conjunction with a 1-micrograms oxacillin disk. A 30-micrograms cefuroxime disk is proposed: strains with zones > or = 28 mm in diameter are predictably susceptible to cefotaxime and ceftriaxone, and those with smaller zones should be further studied to confirm resistance to either drug. A 30-micrograms ceftizoxime disk may also be used as a screening test with zones > or = 26 mm indicating susceptibility, but cefuroxime disks are preferred.
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Selected References
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- Barry A. L., Brown S. D., Novick W. J. Criteria for testing the susceptibility of Streptococcus pneumoniae to cefotaxime and its desacetyl metabolite using 1 microgram or 30 micrograms cefotaxime disks. Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):724–726. doi: 10.1007/BF01690885. [DOI] [PubMed] [Google Scholar]
- Barry A. L., Brown S. D., Novick W. J. In vitro activities of cefotaxime, ceftriaxone, ceftazidime, cefpirome, and penicillin against Streptococcus pneumoniae isolates. Antimicrob Agents Chemother. 1995 Oct;39(10):2193–2196. doi: 10.1128/aac.39.10.2193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barry A. L., Fuchs P. C. Methods for predicting susceptibility of Streptococcus pneumoniae to cefixime. J Clin Microbiol. 1995 Apr;33(4):1031–1033. doi: 10.1128/jcm.33.4.1031-1033.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barry A. L., Pfaller M. A., Fuchs P. C., Packer R. R. In vitro activities of 12 orally administered antimicrobial agents against four species of bacterial respiratory pathogens from U.S. Medical Centers in 1992 and 1993. Antimicrob Agents Chemother. 1994 Oct;38(10):2419–2425. doi: 10.1128/aac.38.10.2419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradley J. S., Connor J. D. Ceftriaxone failure in meningitis caused by Streptococcus pneumoniae with reduced susceptibility to beta-lactam antibiotics. Pediatr Infect Dis J. 1991 Nov;10(11):871–873. [PubMed] [Google Scholar]
- Catalán M. J., Fernández J. M., Vazquez A., Varela de Seijas E., Suárez A., Bernaldo de Quirós J. C. Failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae. Clin Infect Dis. 1994 May;18(5):766–769. doi: 10.1093/clinids/18.5.766. [DOI] [PubMed] [Google Scholar]
- Doern G. V., Brueggemann A., Holley H. P., Jr, Rauch A. M. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother. 1996 May;40(5):1208–1213. doi: 10.1128/aac.40.5.1208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friedland I. R., Shelton S., McCracken G. H., Jr Screening for cephalosporin-resistant Streptococcus pneumoniae with the Kirby-Bauer disk susceptibility test. J Clin Microbiol. 1993 Jun;31(6):1619–1621. doi: 10.1128/jcm.31.6.1619-1621.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friedland I. R., Shelton S., Paris M., Rinderknecht S., Ehrett S., Krisher K., McCracken G. H., Jr Dilemmas in diagnosis and management of cephalosporin-resistant Streptococcus pneumoniae meningitis. Pediatr Infect Dis J. 1993 Mar;12(3):196–200. doi: 10.1097/00006454-199303000-00004. [DOI] [PubMed] [Google Scholar]
- John C. C. Treatment failure with use of a third-generation cephalosporin for penicillin-resistant pneumococcal meningitis: case report and review. Clin Infect Dis. 1994 Feb;18(2):188–193. doi: 10.1093/clinids/18.2.188. [DOI] [PubMed] [Google Scholar]
- Jorgensen J. H., Swenson J. M., Tenover F. C., Ferraro M. J., Hindler J. A., Murray P. R. Development of interpretive criteria and quality control limits for broth microdilution and disk diffusion antimicrobial susceptibility testing of Streptococcus pneumoniae. J Clin Microbiol. 1994 Oct;32(10):2448–2459. doi: 10.1128/jcm.32.10.2448-2459.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swenson J. M., Hill B. C., Thornsberry C. Screening pneumococci for penicillin resistance. J Clin Microbiol. 1986 Nov;24(5):749–752. doi: 10.1128/jcm.24.5.749-752.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tenover F. C., Baker C. N., Swenson J. M. Evaluation of commercial methods for determining antimicrobial susceptibility of Streptococcus pneumoniae. J Clin Microbiol. 1996 Jan;34(1):10–14. doi: 10.1128/jcm.34.1.10-14.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tenover F. C., Swenson J. M., McDougal L. K. Screening for extended-spectrum cephalosporin resistance in pneumococci. Lancet. 1992 Dec 5;340(8832):1420–1420. doi: 10.1016/0140-6736(92)92617-o. [DOI] [PubMed] [Google Scholar]