Abstract
Among preschool children, we found an association between cytomegalovirus (CMV) infection and salivary immunoglobulin G antibodies to CMV glycoprotein B. All of the 20 infected children had immunoglobulin G to CMV glycoprotein B in their saliva, whereas 38 of 38 uninfected children lacked these antibodies. Testing saliva provides a sensitive and specific alternative to obtaining serum.
Full Text
The Full Text of this article is available as a PDF (146.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adler S. P. Cytomegalovirus and child day care. Evidence for an increased infection rate among day-care workers. N Engl J Med. 1989 Nov 9;321(19):1290–1296. doi: 10.1056/NEJM198911093211903. [DOI] [PubMed] [Google Scholar]
- Adler S. P. Cytomegalovirus and child day care: risk factors for maternal infection. Pediatr Infect Dis J. 1991 Aug;10(8):590–594. doi: 10.1097/00006454-199108000-00008. [DOI] [PubMed] [Google Scholar]
- Adler S. P., Finney J. W., Manganello A. M., Best A. M. Prevention of child-to-mother transmission of cytomegalovirus by changing behaviors: a randomized controlled trial. Pediatr Infect Dis J. 1996 Mar;15(3):240–246. doi: 10.1097/00006454-199603000-00013. [DOI] [PubMed] [Google Scholar]
- Adler S. P. Molecular epidemiology of cytomegalovirus: a study of factors affecting transmission among children at three day-care centers. Pediatr Infect Dis J. 1991 Aug;10(8):584–590. [PubMed] [Google Scholar]
- Adler S. P. Molecular epidemiology of cytomegalovirus: evidence for viral transmission to parents from children infected at a day care center. Pediatr Infect Dis. 1986 May-Jun;5(3):315–318. [PubMed] [Google Scholar]
- Brytting M., Sundqvist V. A., Stålhandske P., Linde A., Wahren B. Cytomegalovirus DNA detection of an immediate early protein gene with nested primer oligonucleotides. J Virol Methods. 1991 May;32(2-3):127–138. doi: 10.1016/0166-0934(91)90043-y. [DOI] [PubMed] [Google Scholar]
- Murph J. R., Baron J. C., Brown C. K., Ebelhack C. L., Bale J. F., Jr The occupational risk of cytomegalovirus infection among day-care providers. JAMA. 1991 Feb 6;265(5):603–608. [PubMed] [Google Scholar]
- Pass R. F., Hutto C., Lyon M. D., Cloud G. Increased rate of cytomegalovirus infection among day care center workers. Pediatr Infect Dis J. 1990 Jul;9(7):465–470. doi: 10.1097/00006454-199007000-00003. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Hutto C., Ricks R., Cloud G. A. Increased rate of cytomegalovirus infection among parents of children attending day-care centers. N Engl J Med. 1986 May 29;314(22):1414–1418. doi: 10.1056/NEJM198605293142204. [DOI] [PubMed] [Google Scholar]
- Stagno S., Pass R. F., Cloud G., Britt W. J., Henderson R. E., Walton P. D., Veren D. A., Page F., Alford C. A. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome. JAMA. 1986 Oct 10;256(14):1904–1908. [PubMed] [Google Scholar]
- Wang J. B., Adler S. P., Hempfling S., Burke R. L., Duliège A. M., Starr S. E., Plotkin S. A. Mucosal antibodies to human cytomegalovirus glycoprotein B occur following both natural infection and immunization with human cytomegalovirus vaccines. J Infect Dis. 1996 Aug;174(2):387–392. doi: 10.1093/infdis/174.2.387. [DOI] [PubMed] [Google Scholar]