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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1997 Jul;35(7):1873–1875. doi: 10.1128/jcm.35.7.1873-1875.1997

Increased prevalence of genotype F hepatitis B virus isolates in Buenos Aires, Argentina.

P F Telenta 1, G P Poggio 1, J L López 1, J Gonzalez 1, A Lemberg 1, R H Campos 1
PMCID: PMC229861  PMID: 9196213

Abstract

The genomic coding region of the hepatitis B surface antigen (HBsAg) was partially sequenced from 12 HBsAg-positive sera of carriers residing in Buenos Aires, Argentina. A phylogenetic analysis groups the 12 isolates into genotypes A (n = 4), B (n = 1), D (n = 2), and F (n = 5). The occurrence of genotypes A and D is not unexpected, considering the mainly European origin of the studied population. The high prevalence of genotype F and its genetic composition support the suggestion that F strains originated in native populations of the New World.

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Selected References

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  1. Carman W. F., Korula J., Wallace L., MacPhee R., Mimms L., Decker R. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet. 1995 Jun 3;345(8962):1406–1407. doi: 10.1016/s0140-6736(95)92599-6. [DOI] [PubMed] [Google Scholar]
  2. Carman W. F., Zanetti A. R., Karayiannis P., Waters J., Manzillo G., Tanzi E., Zuckerman A. J., Thomas H. C. Vaccine-induced escape mutant of hepatitis B virus. Lancet. 1990 Aug 11;336(8711):325–329. doi: 10.1016/0140-6736(90)91874-a. [DOI] [PubMed] [Google Scholar]
  3. Couroucé-Pauty A. M., Lemaire J. M., Roux J. F. New hepatitis B surface antigen subtypes inside the ad category. Vox Sang. 1978;35(5):304–308. doi: 10.1111/j.1423-0410.1978.tb02939.x. [DOI] [PubMed] [Google Scholar]
  4. Couroucé-Pauty A. M., Plançon A., Soulier J. P. Distribution of HBsAg subtypes in the world. Vox Sang. 1983;44(4):197–211. doi: 10.1111/j.1423-0410.1983.tb01885.x. [DOI] [PubMed] [Google Scholar]
  5. Galibert F., Mandart E., Fitoussi F., Tiollais P., Charnay P. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature. 1979 Oct 25;281(5733):646–650. doi: 10.1038/281646a0. [DOI] [PubMed] [Google Scholar]
  6. Gaspar A. M., Yoshida C. F. Geographic distribution of HBsAg subtypes in Brazil. Mem Inst Oswaldo Cruz. 1987 Apr-Jun;82(2):253–258. doi: 10.1590/s0074-02761987000200013. [DOI] [PubMed] [Google Scholar]
  7. Harrison T. J., Hopes E. A., Oon C. J., Zanetti A. R., Zuckerman A. J. Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J Hepatol. 1991;13 (Suppl 4):S105–S107. doi: 10.1016/0168-8278(91)90037-c. [DOI] [PubMed] [Google Scholar]
  8. Higgins D. G., Bleasby A. J., Fuchs R. CLUSTAL V: improved software for multiple sequence alignment. Comput Appl Biosci. 1992 Apr;8(2):189–191. doi: 10.1093/bioinformatics/8.2.189. [DOI] [PubMed] [Google Scholar]
  9. Holland P. V. Practical problems for HBSAg subtyping. Bibl Haematol. 1976;42:1–11. doi: 10.1159/000398977. [DOI] [PubMed] [Google Scholar]
  10. Magnius L. O., Norder H. Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology. 1995;38(1-2):24–34. doi: 10.1159/000150411. [DOI] [PubMed] [Google Scholar]
  11. McMahon G., Ehrlich P. H., Moustafa Z. A., McCarthy L. A., Dottavio D., Tolpin M. D., Nadler P. I., Ostberg L. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology. 1992 May;15(5):757–766. doi: 10.1002/hep.1840150503. [DOI] [PubMed] [Google Scholar]
  12. Norder H., Couroucé A. M., Magnius L. O. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology. 1994 Feb;198(2):489–503. doi: 10.1006/viro.1994.1060. [DOI] [PubMed] [Google Scholar]
  13. Norder H., Hammas B., Lee S. D., Bile K., Couroucé A. M., Mushahwar I. K., Magnius L. O. Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. J Gen Virol. 1993 Jul;74(Pt 7):1341–1348. doi: 10.1099/0022-1317-74-7-1341. [DOI] [PubMed] [Google Scholar]
  14. Okamoto H., Tsuda F., Sakugawa H., Sastrosoewignjo R. I., Imai M., Miyakawa Y., Mayumi M. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988 Oct;69(Pt 10):2575–2583. doi: 10.1099/0022-1317-69-10-2575. [DOI] [PubMed] [Google Scholar]
  15. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tong S. P., Li J. S., Vitvitski L., Trépo C. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology. 1990 Jun;176(2):596–603. doi: 10.1016/0042-6822(90)90030-u. [DOI] [PubMed] [Google Scholar]
  17. Yokosuka O., Omata M., Hosoda K., Tada M., Ehata T., Ohto M. Detection and direct sequencing of hepatitis B virus genome by DNA amplification method. Gastroenterology. 1991 Jan;100(1):175–181. doi: 10.1016/0016-5085(91)90598-f. [DOI] [PubMed] [Google Scholar]

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