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. 1997 Nov;35(11):2999–3000. doi: 10.1128/jcm.35.11.2999-3000.1997

Immunoglobulin A antibodies to Helicobacter pylori.

T D Jaskowski 1, T B Martins 1, H R Hill 1, C M Litwin 1
PMCID: PMC230107  PMID: 9350779

Abstract

Serological testing for immunoglobulin G (IgG) antibodies to Helicobacter pylori has proven useful in supporting the diagnosis of infection with this organism, but the clinical value of IgA antibodies in H. pylori-related gastritis remains controversial. The purpose of our study was to determine the frequency of IgA-positive IgG-negative patients with symptoms of gastrointestinal (GI) disorders, thus assessing the clinical utility of IgA testing for H. pylori-related gastritis. It was found previously that the frequency of infected individuals in this category (IgA positive and IgG negative) is about 2%, but a large number of IgG-negative patients with GI disorders suggestive of H. pylori infection have not been investigated until now.

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Selected References

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  1. Aromaa A., Kosunen T. U., Knekt P., Maatela J., Teppo L., Heinonen O. P., Härkönen M., Hakama M. K. Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer. Am J Epidemiol. 1996 Jul 15;144(2):142–149. doi: 10.1093/oxfordjournals.aje.a008901. [DOI] [PubMed] [Google Scholar]
  2. Blaser M. J. Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology. 1987 Aug;93(2):371–383. doi: 10.1016/0016-5085(87)91028-6. [DOI] [PubMed] [Google Scholar]
  3. Cutler A., Schubert A., Schubert T. Role of Helicobacter pylori serology in evaluating treatment success. Dig Dis Sci. 1993 Dec;38(12):2262–2266. doi: 10.1007/BF01299906. [DOI] [PubMed] [Google Scholar]
  4. Graham D. Y., Klein P. D., Evans D. J., Jr, Evans D. G., Alpert L. C., Opekun A. R., Boutton T. W. Campylobacter pylori detected noninvasively by the 13C-urea breath test. Lancet. 1987 May 23;1(8543):1174–1177. doi: 10.1016/s0140-6736(87)92145-3. [DOI] [PubMed] [Google Scholar]
  5. Granberg C., Mansikka A., Lehtonen O. P., Kujari H., Grönfors R., Nurmi H., Räihä I., Ståhlberg M. R., Leino R. Diagnosis of Helicobacter pylori infection by using pyloriset EIA-G and EIA-A for detection of serum immunoglobulin G (IgG) and IgA antibodies. J Clin Microbiol. 1993 Jun;31(6):1450–1453. doi: 10.1128/jcm.31.6.1450-1453.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kosunen T. U., Seppälä K., Sarna S., Sipponen P. Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pylori. Lancet. 1992 Apr 11;339(8798):893–895. doi: 10.1016/0140-6736(92)90929-w. [DOI] [PubMed] [Google Scholar]
  7. Morris A. J., Ali M. R., Nicholson G. I., Perez-Perez G. I., Blaser M. J. Long-term follow-up of voluntary ingestion of Helicobacter pylori. Ann Intern Med. 1991 Apr 15;114(8):662–663. doi: 10.7326/0003-4819-114-8-662. [DOI] [PubMed] [Google Scholar]
  8. Nowak J. A. Limitation of histology for detecting Helicobacter pylori. Gastrointest Endosc. 1995 Feb;41(2):175–177. doi: 10.1016/s0016-5107(05)80609-1. [DOI] [PubMed] [Google Scholar]
  9. Parsonnet J. Helicobacter pylori and gastric cancer. Gastroenterol Clin North Am. 1993 Mar;22(1):89–104. [PubMed] [Google Scholar]
  10. Perez-Perez G. I., Dworkin B. M., Chodos J. E., Blaser M. J. Campylobacter pylori antibodies in humans. Ann Intern Med. 1988 Jul 1;109(1):11–17. doi: 10.7326/0003-4819-109-1-11. [DOI] [PubMed] [Google Scholar]
  11. Testoni P. A., Colombo E., Cattani L., Longhi M., Bagnolo F., Lella F., Buizza M., Scelsi R. Helicobacter pylori serology in chronic gastritis with antral atrophy and negative histology for Helicobacter-like organisms. J Clin Gastroenterol. 1996 Apr;22(3):182–185. doi: 10.1097/00004836-199604000-00006. [DOI] [PubMed] [Google Scholar]
  12. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  13. Vaira D., Holton J., Cairns S. R., Falzon M., Polydorou A., Dowsett J. F., Salmon P. R. Antibody titres to Campylobacter pylori after treatment for gastritis. BMJ. 1988 Aug 6;297(6645):397–397. doi: 10.1136/bmj.297.6645.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Veenendaal R. A., Peña A. S., Meijer J. L., Endtz H. P., van der Est M. M., van Duijn W., Eulderink F., Kreuning J., Lamers C. B. Long term serological surveillance after treatment of Helicobacter pylori infection. Gut. 1991 Nov;32(11):1291–1294. doi: 10.1136/gut.32.11.1291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Yamamoto I., Fukuda Y., Mizuta T., Fukada M., Nishigami T., Shimoyama T. Serum anti-Helicobacter pylori antibodies and gastritis. J Clin Gastroenterol. 1995;21 (Suppl 1):S164–S168. [PubMed] [Google Scholar]

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