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. 1997 Jan;17(1):1–9. doi: 10.1128/mcb.17.1.1

The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression.

C Kannabiran 1, X Zeng 1, L D Vales 1
PMCID: PMC231723  PMID: 8972179

Abstract

The cellular interleukin-6 (IL-6) gene contains a target site for the mammalian transcriptional repressor RBP. The target site is contained within the interleukin response element (ILRE), which mediates IL-6 activation by NF-kappa B. In this study, we show by using transient-expression assays that RBP represses activated transcription from the IL-6 gene. The presence and position of the RBP target site are crucial in mediating repression by RBP. While RBP binds within the ILRE, it does not target NF-kappa B alone; nonetheless, NF-kappa B binding to the ILRE is required for repression. Our results indicate that RBP represses coactivation by NF-kappa B and another cellular transcription factor, C/EBP-beta.

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Selected References

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