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. 1996 Jul;178(13):3974–3977. doi: 10.1128/jb.178.13.3974-3977.1996

PstB protein of the phosphate-specific transport system of Escherichia coli is an ATPase.

F Y Chan 1, A Torriani 1
PMCID: PMC232664  PMID: 8682808

Abstract

The PstB protein of the phosphate-specific transport (Pst) system of Escherichia coli bound and hydrolyzed ATP, producing ADP. Urea-treated denatured PstB did not bind ATP. The N-terminal amino acid sequence of the immune serum-precipitable PstB protein was determined, and it corresponded to that deduced from the DNA sequence.

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Selected References

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  1. Amemura M., Makino K., Shinagawa H., Kobayashi A., Nakata A. Nucleotide sequence of the genes involved in phosphate transport and regulation of the phosphate regulon in Escherichia coli. J Mol Biol. 1985 Jul 20;184(2):241–250. doi: 10.1016/0022-2836(85)90377-8. [DOI] [PubMed] [Google Scholar]
  2. Ames G. F., Mimura C. S., Holbrook S. R., Shyamala V. Traffic ATPases: a superfamily of transport proteins operating from Escherichia coli to humans. Adv Enzymol Relat Areas Mol Biol. 1992;65:1–47. doi: 10.1002/9780470123119.ch1. [DOI] [PubMed] [Google Scholar]
  3. Ames G. F., Mimura C. S., Shyamala V. Bacterial periplasmic permeases belong to a family of transport proteins operating from Escherichia coli to human: Traffic ATPases. FEMS Microbiol Rev. 1990 Aug;6(4):429–446. doi: 10.1111/j.1574-6968.1990.tb04110.x. [DOI] [PubMed] [Google Scholar]
  4. Bishop L., Agbayani R., Jr, Ambudkar S. V., Maloney P. C., Ames G. F. Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport. Proc Natl Acad Sci U S A. 1989 Sep;86(18):6953–6957. doi: 10.1073/pnas.86.18.6953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cox G. B., Rosenberg H., Downie J. A., Silver S. Genetic analysis of mutants affected in the Pst inorganic phosphate transport system. J Bacteriol. 1981 Oct;148(1):1–9. doi: 10.1128/jb.148.1.1-9.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cox G. B., Webb D., Rosenberg H. Specific amino acid residues in both the PstB and PstC proteins are required for phosphate transport by the Escherichia coli Pst system. J Bacteriol. 1989 Mar;171(3):1531–1534. doi: 10.1128/jb.171.3.1531-1534.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Doige C. A., Ames G. F. ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistance. Annu Rev Microbiol. 1993;47:291–319. doi: 10.1146/annurev.mi.47.100193.001451. [DOI] [PubMed] [Google Scholar]
  8. Higgins C. F., Gallagher M. P., Mimmack M. L., Pearce S. R. A family of closely related ATP-binding subunits from prokaryotic and eukaryotic cells. Bioessays. 1988 Apr;8(4):111–116. doi: 10.1002/bies.950080406. [DOI] [PubMed] [Google Scholar]
  9. Higgins C. F., Hiles I. D., Whalley K., Jamieson D. J. Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems. EMBO J. 1985 Apr;4(4):1033–1039. doi: 10.1002/j.1460-2075.1985.tb03735.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hobson A. C., Weatherwax R., Ames G. F. ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7333–7337. doi: 10.1073/pnas.81.23.7333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Knight K. L., McEntee K. Covalent modification of the recA protein from Escherichia coli with the photoaffinity label 8-azidoadenosine 5'-triphosphate. J Biol Chem. 1985 Jan 25;260(2):867–872. [PubMed] [Google Scholar]
  12. Madiraju M. V., Clark A. J. Evidence for ATP binding and double-stranded DNA binding by Escherichia coli RecF protein. J Bacteriol. 1992 Dec;174(23):7705–7710. doi: 10.1128/jb.174.23.7705-7710.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Muda M., Rao N. N., Torriani A. Role of PhoU in phosphate transport and alkaline phosphatase regulation. J Bacteriol. 1992 Dec;174(24):8057–8064. doi: 10.1128/jb.174.24.8057-8064.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rao N. N., Torriani A. Molecular aspects of phosphate transport in Escherichia coli. Mol Microbiol. 1990 Jul;4(7):1083–1090. doi: 10.1111/j.1365-2958.1990.tb00682.x. [DOI] [PubMed] [Google Scholar]
  15. Selwyn M. J. Preparation and general properties of a soluble adenosine triphosphatase from mitochondria. Biochem J. 1967 Oct;105(1):279–288. doi: 10.1042/bj1050279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Studier F. W., Rosenberg A. H., Dunn J. J., Dubendorff J. W. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 1990;185:60–89. doi: 10.1016/0076-6879(90)85008-c. [DOI] [PubMed] [Google Scholar]
  17. Surin B. P., Rosenberg H., Cox G. B. Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships. J Bacteriol. 1985 Jan;161(1):189–198. doi: 10.1128/jb.161.1.189-198.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Torriani A. From cell membrane to nucleotides: the phosphate regulon in Escherichia coli. Bioessays. 1990 Aug;12(8):371–376. doi: 10.1002/bies.950120804. [DOI] [PubMed] [Google Scholar]
  19. Walter C., Höner zu Bentrup K., Schneider E. Large scale purification, nucleotide binding properties, and ATPase activity of the MalK subunit of Salmonella typhimurium maltose transport complex. J Biol Chem. 1992 May 5;267(13):8863–8869. [PubMed] [Google Scholar]
  20. Webb D. C., Rosenberg H., Cox G. B. Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices. J Biol Chem. 1992 Dec 5;267(34):24661–24668. [PubMed] [Google Scholar]
  21. Zuckier G., Torriani A. Genetic and physiological tests of three phosphate-specific transport mutants of Escherichia coli. J Bacteriol. 1981 Mar;145(3):1249–1256. doi: 10.1128/jb.145.3.1249-1256.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]

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