Table 2.
Mean reciprocal antibody titres measured in sera and secretions of mice after three oral or i.n. doses of OVA, PHA, WGA and UEA‐1. The number of responding mice and total number of mice in each group are in parentheses. Mice were immunized i.n. or orally with 10 µg or 100 µg OVA/lectin, respectively. Endpoint titres were determined as the lowest dilution of test sample giving an absorbance of greater than 0·1 units higher than control samples at the same dilution
| Lectin (route) | IgG serum | IgG1 serum | IgG2a serum | IgG2b serum | IgG3 serum | IgA serum | IgA saliva | IgA vagina | IgA nasal | IgA gut |
|---|---|---|---|---|---|---|---|---|---|---|
| OVA oral | 40 (4/10) | – | – | – | – | – | – | – | – | 1·6 (1/10) |
| OVA i.n. | 50 (5/10) | – | – | – | – | 70 (6/10) | – | – | – | – |
| PHA oral | 290 (6/10) | 241 (6/10) | 10 (1/10) | – | – | 450 (9/10) | – | – | – | 1·6 (2/10) |
| PHA i.n. | 800 (10/10) | 841 (10/10) | – | – | – | 410 (7/10) | – | – | – | 2 (4/10) |
| WGA oral | 500 (10/10) | 131 (5/10) | – | – | – | 200 (9/10) | – | – | – | – |
| WGA i.n. | 130 (9/10) | – | – | – | – | 190 (8/10) | – | – | – | – |
| UEA‐1 oral | 3770 (9/10) | 671 (8/10) | – | – | – | 200 (7/10) | – | – | – | 1·2 (3/10) |
| UEA‐1 i.n. | 673 (6/10) | 101 (6/10) | – | – | – | 173 (9/10) | – | – | 0·4 (2/10) | 0·9 (2/10) |