Figure 1.

The effect of cultured supernatants from 9A4, 9D7, 12B3 and NS-1 cells and purified mouse IgG on [³H]thymidine incorporation of PHA (2 µg/ml)-stimulated normal human mononuclear cells (MNC + PHA) and cultured rat glomerular mesangial cells (RMC) after incubation for 3 days. (a) The concentration of different proteins: mouse IgG = 20 µg/ml, 9A4 = 0·06 µg/ml, 9D7 = 12·8 µg/ml, 12B3 = 11·04 µg/ml and NS-1 = 2·5× dilution. (b) Dose–response effect of different proteins on [³H]thymidine incorporation of PHA-stimulated MNC. The concentration of 1× dilution of different proteins was as the same as in (a). * denotes P < 0·05.