Abstract
Severe drug-induced thrombocytopenia (DIT) is a relatively rare, but potentially lethal, complication of pharmacological therapy. Quinine, a drug commonly used for the treatment of leg cramps, is one of the most frequent causes of DIT. This article reports a case of quinine-induced thrombocytopenia (QIT) and reviews the literature on the subject.
Keywords: thrombocytopenia, quinine, idiopathic thrombocytopenia purpura
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- ACKROYD J. F. The immunological basis of purpura due to drug hypersensitivity. Proc R Soc Med. 1962 Jan;55:30–36. [PMC free article] [PubMed] [Google Scholar]
- BIGELOW F. S., DESFORGES J. F. Platelet agglutination by an abnormal plasma factor in thrombocytopenic purpura associated with quinidine ingestion. Am J Med Sci. 1952 Sep;224(3):274–280. doi: 10.1097/00000441-195209000-00004. [DOI] [PubMed] [Google Scholar]
- BOLTON F. G., YOUNG R. V. Observations on cases of thrombocytopenic purpura due to quinine, sulphamezathine, and quinidine. J Clin Pathol. 1953 Nov;6(4):320–323. doi: 10.1136/jcp.6.4.320. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BROST U. Schwarzer Urin (Schwarzwasser) nach Chininanwendung in der Schwangerschaft. Geburtshilfe Frauenheilkd. 1956 Aug;16(8):698–706. [PubMed] [Google Scholar]
- Barrett A. P., Tversky J., Griffiths C. J. Thrombocytopenia induced by quinine. Oral Surg Oral Med Oral Pathol. 1983 Apr;55(4):351–354. doi: 10.1016/0030-4220(83)90188-3. [DOI] [PubMed] [Google Scholar]
- Belkin G. A. Cocktail purpura. An unusual case of quinine sensitivity. Ann Intern Med. 1967 Mar;66(3):583–586. doi: 10.7326/0003-4819-66-3-583. [DOI] [PubMed] [Google Scholar]
- Burgess M. A., Hirsh J., de Gruchy G. C. Acute thrombocytopenic purpura due to quinine sensitivity. Med J Aust. 1969 Mar 1;1(9):453–456. doi: 10.5694/j.1326-5377.1969.tb92213.x. [DOI] [PubMed] [Google Scholar]
- Christie D. J., Aster R. H. Drug-antibody-platelet interaction in quinine- and quinidine-induced thrombocytopenia. J Clin Invest. 1982 Nov;70(5):989–998. doi: 10.1172/JCI110710. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Christie D. J., Walker R. H., Kolins M. D., Wilner F. M., Aster R. H. Quinine-induced thrombocytopenia following intravenous use of heroin. Arch Intern Med. 1983 Jun;143(6):1174–1175. [PubMed] [Google Scholar]
- DEVAUX W., LAHEY M. E., MAUER A. M. Neonatal and maternal thrombocytopenic purpura due to quinine. Pediatrics. 1957 Jan;19(1):84–87. [PubMed] [Google Scholar]
- EGELI E. S., BERKMEN R., INCEMAN S., OZBEK A. Kinine bağli allerjik trombositopenik purpura. Turk Tip Cemiy Mecm. 1958 Mar;24(3):159–168. [PubMed] [Google Scholar]
- Hackett T., Kelton J. G., Powers P. Drug-induced platelet destruction. Semin Thromb Hemost. 1982 Apr;8(2):116–137. doi: 10.1055/s-2007-1005047. [DOI] [PubMed] [Google Scholar]
- Helmly R. B., Bergin J. J., Shulman N. R. Quinine-induced purpura. Observation on antibody titers. Arch Intern Med. 1967 Jul;120(1):59–62. [PubMed] [Google Scholar]
- Hosseinzadeh P. K., Firkin B. G., Pfueller S. L. Study of the factors that cause specific transformation in cultures of lymphocytes from patients with quinine- and quinidine-induced immune thrombocytopenia. J Clin Invest. 1980 Oct;66(4):638–645. doi: 10.1172/JCI109899. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
- KISSMEYER-NIELSEN F. Thrombocytopenic purpura following quinine medication; an immunological study. Acta Med Scand. 1956 May 26;154(4):289–298. doi: 10.1111/j.0954-6820.1956.tb14323.x. [DOI] [PubMed] [Google Scholar]
- LARSON R. K. The mechanism of quinidine purpura. Blood. 1953 Jan;8(1):16–25. [PubMed] [Google Scholar]
- LEVINE S. Thrombocytopenic purpura due to quinine, with oral symptoms; report of a case. Oral Surg Oral Med Oral Pathol. 1959 Jun;12(6):692–695. doi: 10.1016/0030-4220(59)90114-8. [DOI] [PubMed] [Google Scholar]
- Murray J. A., Abbott I., Anderson D. A., Morgan A. D. Bitter lemon purpura. Br Med J. 1979 Dec 15;2(6204):1551–1552. doi: 10.1136/bmj.2.6204.1551-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NORBERG C. Acetylkinin; haemorrhagisk diathese. Nord Med. 1953 May 1;49(18):648–649. [PubMed] [Google Scholar]
- Rennie T., Freilich R., Kotkis S. J., Catania A. Sequelae of dental extraction during quinine-induced thrombocytopenia. J Oral Surg. 1976 Mar;34(3):272–275. [PubMed] [Google Scholar]
- Rosa S., Neligh R. B. Thrombocytopenia due to quinidine sensitivity. J Iowa Med Soc. 1979 Aug;69(8):315–317. [PubMed] [Google Scholar]
- SHULMAN N. R. Immunoreactions involving platelets. III. Quantitative aspects of platelet agglutination, inhibition of clot retraction, and other reactions caused by the antibody of quinidine purpura. J Exp Med. 1958 May 1;107(5):697–710. doi: 10.1084/jem.107.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEINKAMP R., MOORE C. V., DOUBEK W. G. Thrombocytopenic purpura caused by hypersensitivity to quinine. J Lab Clin Med. 1955 Jan;45(1):18–29. [PubMed] [Google Scholar]
- Tiliakos N., Waites T. F. Multiform quinidine toxicity. South Med J. 1981 Oct;74(10):1267–1268. doi: 10.1097/00007611-198110000-00034. [DOI] [PubMed] [Google Scholar]
- WEINTRAUB R. M., PECHET L., ALEXANDER B. Rapid diagnosis of drug-induced thrombocytopenic purpura. Report of three cases due to quinine, quinidine, and Dilantin. JAMA. 1962 May 19;180:528–532. doi: 10.1001/jama.1962.03050200012004. [DOI] [PubMed] [Google Scholar]
- WEISFUSE L., SPEAR P. W., SASS M. Quinidine-induced thrombocytopenic purpura; report of a fourteenth case and review of clinical and experimental studies. Am J Med. 1954 Sep;17(3):414–422. doi: 10.1016/0002-9343(54)90251-x. [DOI] [PubMed] [Google Scholar]