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. 1992;12:35–41.

The Morphology of the Long Bone Physis in Hypochondroplasia and Comparison with Other Growth Disorders

Frederick R Dietz, Blayne L Fritz, Laura J Trombino, Jerry Maynard
PMCID: PMC2328748

Abstract

The morphology of fibular physes from three growth disorders (achondroplasia, hypochondroplasia, and pseudoachondroplasia) were compared with normal physes. All growth disorders' physes were abnormal with the most consistent abnormality occurring in the hypertrophic zone (HZ). Marked shortening of the HZ was seen in the hypochondroplast and the achondroplast. The shortening of the HZ was more severe in the achondroplast compared to the hypochondroplast. Good column formation was present in most of the physis in both of these disorders. Disorganization of the entire physis was present in pseudoachondroplasia.

These observations are consistent with the hypothesis that physeal elongation is driven by HZ cell enlargement directed longitudinally by the extra cellular matrix. These observations suggest that abnormal HZ function may be the final common pathway of growth disorders.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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