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. 1976 Oct;128(1):510–513. doi: 10.1128/jb.128.1.510-513.1976

Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification.

K J Andrews, E C Lin
PMCID: PMC232886  PMID: 789355

Abstract

Thigalactoside transacetylase, the lacA gene product, confers selective advantage to cells of Escherichia coli K-12 growing on beta-galactosides in the presence of non-metabolizable analogues.

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Selected References

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  1. ALPERS D. H., APPEL S. H., TOMKINS G. M. A SPECTROPHOTOMETRIC ASSAY FOR THIOGALACTOSIDE TRANSACETYLASE. J Biol Chem. 1965 Jan;240:10–13. [PubMed] [Google Scholar]
  2. Andrews K. J., Lin E. C. Selective advantages of various bacterial carbohydrate transport mechanisms. Fed Proc. 1976 Aug;35(10):2185–2189. [PubMed] [Google Scholar]
  3. BURSTEIN C., COHN M., KEPES A., MONOD J. R OLE DU LACTOSE ET DE SES PRODUITS M'ETABOLIQUES DANS L'INDUCTION DE L'OP'ERON LACTOSE CHEZ ESCHERICHIA COLI. Biochim Biophys Acta. 1965 Apr 19;95:634–639. [PubMed] [Google Scholar]
  4. Benveniste R., Davies J. Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem. 1973;42:471–506. doi: 10.1146/annurev.bi.42.070173.002351. [DOI] [PubMed] [Google Scholar]
  5. Davies J. E., Rownd R. Transmissible multiple drug resistance in Enterobacteriaceae. Science. 1972 May 19;176(4036):758–768. doi: 10.1126/science.176.4036.758. [DOI] [PubMed] [Google Scholar]
  6. De Crombrugghe B., Pastan I., Shaw W. V., Rosner J. L. Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis. Nat New Biol. 1973 Feb 21;241(112):237–239. doi: 10.1038/newbio241237a0. [DOI] [PubMed] [Google Scholar]
  7. Fox C. F., Beckwith J. R., Epstein W., Signer E. R. Transposition of the lac region of Escherichia coli. II. On the role of thiogalactoside transacetylase in lactose metabolism. J Mol Biol. 1966 Aug;19(2):576–579. doi: 10.1016/s0022-2836(66)80025-6. [DOI] [PubMed] [Google Scholar]
  8. HAGIHIRA H., WILSON T. H., LIN E. C. STUDIES ON THE GLUCOSE-TRANSPORT SYSTEM IN ESCHERICHIA COLI WITH ALPHA-METHYLGLUCOSIDE AS SUBSTRATE. Biochim Biophys Acta. 1963 Nov 15;78:505–515. doi: 10.1016/0006-3002(63)90912-0. [DOI] [PubMed] [Google Scholar]
  9. HERZENBERG L. A. Isolation and identification of derivatives formed in the course of intracellular accumulation of thiogalactosides by Escherichia coli. Arch Biochem Biophys. 1961 May;93:314–315. doi: 10.1016/0003-9861(61)90270-3. [DOI] [PubMed] [Google Scholar]
  10. Harwood J., Smith D. H. Catabolite repression of chloramphenicol acetyl transferase synthesis in E. coli K12. Biochem Biophys Res Commun. 1971 Jan 8;42(1):57–62. doi: 10.1016/0006-291x(71)90361-5. [DOI] [PubMed] [Google Scholar]
  11. Hengstenberg W., Egan J. B., Morse M. L. Carbohydrate transport in Staphylococcus aureus. V. The accumulation of phosphorylated carbohydrate derivatives, and evidence for a new enzyme-splitting lactose phosphate. Proc Natl Acad Sci U S A. 1967 Jul;58(1):274–279. doi: 10.1073/pnas.58.1.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jobe A., Bourgeois S. lac Repressor-operator interaction. VI. The natural inducer of the lac operon. J Mol Biol. 1972 Aug 28;69(3):397–408. doi: 10.1016/0022-2836(72)90253-7. [DOI] [PubMed] [Google Scholar]
  13. KEPES A. [Kinetic studies on galactoside permease of Escherichia coli]. Biochim Biophys Acta. 1960 May 6;40:70–84. doi: 10.1016/0006-3002(60)91316-0. [DOI] [PubMed] [Google Scholar]
  14. Kennedy E. P., Scarborough G. A. Mechanism of hydrolysis of O-nitrophenyl-beta-galactoside in Staphylococcus aureus and its significance for theories of sugar transport. Proc Natl Acad Sci U S A. 1967 Jul;58(1):225–228. doi: 10.1073/pnas.58.1.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. LeBlanc D. J., Mortlock R. P. Metabolism of D-arabinose: a new pathway in Escherichia coli. J Bacteriol. 1971 Apr;106(1):90–96. doi: 10.1128/jb.106.1.90-96.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Musso R. E., Zabin I. Substrate specificity and kinetic studies on thiogalactoside transacetylase. Biochemistry. 1973 Jan 30;12(3):553–557. doi: 10.1021/bi00727a031. [DOI] [PubMed] [Google Scholar]
  17. Okamoto S., Suzuki Y. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'. Nature. 1965 Dec 25;208(5017):1301–1303. doi: 10.1038/2081301a0. [DOI] [PubMed] [Google Scholar]
  18. Sridhara S., Wu T. T., Chused T. M., Lin E. C. Ferrous-activated nicotinamide adenine dinucleotide-linked dehydrogenase from a mutant of Escherichia coli capable of growth on 1, 2-propanediol. J Bacteriol. 1969 Apr;98(1):87–95. doi: 10.1128/jb.98.1.87-95.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tsukada I., Yagisawa M., Umezawa M., Hori M., Umezawa H. Stimulation of kanamycin phosphotransferase synthesis in Escherichia coli by 3',5'-cyclic AMP. J Antibiot (Tokyo) 1972 Feb;25(2):144–146. doi: 10.7164/antibiotics.25.144. [DOI] [PubMed] [Google Scholar]
  20. Umezawa H., Okanishi M., Utahara R., Maeda K., Kondo S. Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. J Antibiot (Tokyo) 1967 Jul;20(3):136–141. [PubMed] [Google Scholar]
  21. West I. C. Lactose transport coupled to proton movements in Escherichia coli. Biochem Biophys Res Commun. 1970 Nov 9;41(3):655–661. doi: 10.1016/0006-291x(70)90063-x. [DOI] [PubMed] [Google Scholar]
  22. West I., Mitchell P. Proton-coupled beta-galactoside translocation in non-metabolizing Escherichia coli. J Bioenerg. 1972 Aug;3(5):445–462. doi: 10.1007/BF01516082. [DOI] [PubMed] [Google Scholar]
  23. Wilson T. H., Kashket E. R. Isolation and properties of thiogalactoside transacetylase-negative mutants of Escherichia coli. Biochim Biophys Acta. 1969 Apr;173(3):501–508. doi: 10.1016/0005-2736(69)90014-5. [DOI] [PubMed] [Google Scholar]
  24. Winkler H. H. Efflux and the steady state in alpha-methylglucoside transport in Escherichia coli. J Bacteriol. 1971 May;106(2):362–368. doi: 10.1128/jb.106.2.362-368.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Winkler H. H., Wilson T. H. The role of energy coupling in the transport of beta-galactosides by Escherichia coli. J Biol Chem. 1966 May 25;241(10):2200–2211. [PubMed] [Google Scholar]
  26. ZABIN I. Galactoside transport in relation to bacterial genetics and protein synthesis. Fed Proc. 1963 Jan-Feb;22:27–30. [PubMed] [Google Scholar]
  27. ZABIN I., KEPES A., MONOD J. Thiogalactoside transacetylase. J Biol Chem. 1962 Jan;237:253–257. [PubMed] [Google Scholar]
  28. von HOFSTEN The inhibitory effect of galactosides on the growth of Escherichia coli. Biochim Biophys Acta. 1961 Mar 18;48:164–171. doi: 10.1016/0006-3002(61)90528-5. [DOI] [PubMed] [Google Scholar]

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