Skip to main content
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1976 Sep;127(3):1136–1140. doi: 10.1128/jb.127.3.1136-1140.1976

Synthesis of omega-alicyclic fatty acids from cyclic precursors in Bacillus subtilis.

R Dreher, K Poralla, W A König
PMCID: PMC232904  PMID: 8428

Abstract

A mutant of Bacillus subtilis synthesizes a variety of omega-alicyclic fatty acids when fed with the respective alicyclic carboxylic acids. These fatty acids are: omega-cyclopropane, omega-cyclobutane, omega-cyclopentane, omega-cyclohexane, and omega-cyclohexene fatty acids. These unusual fatty acids did not lead to an inhibition of growth at 37 degrees C and pH 7. The selective advantage of these fatty acids under extrene conditions was studied in comparison with the acidophilic, thermophilic bacterium B. acidocaldarius, which normally contains a high proportion of omega-cyclohexane fatty acids.

Full text

PDF
1136

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bishop D. G., Rutberg L., Samuelsson B. The chemical composition of the cytoplasmic membrane of Bacillus subtilis. Eur J Biochem. 1967 Nov;2(4):448–453. doi: 10.1111/j.1432-1033.1967.tb00158.x. [DOI] [PubMed] [Google Scholar]
  2. De Rosa M., Gambacorta A., Bu'lock J. D. Effects of pH and temperature on the fatty acid composition of bacillus acidocaldarius. J Bacteriol. 1974 Jan;117(1):212–214. doi: 10.1128/jb.117.1.212-214.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kaneda T. Biosynthesis of branched-chain fatty acids. IV. Factors affecting relative abundance of fatty acids produced by Bacillus subtilis. Can J Microbiol. 1966 Jun;12(3):501–514. doi: 10.1139/m66-073. [DOI] [PubMed] [Google Scholar]
  4. Keller-Schierlein W., Poralla K., Zähner H. Stoffwechselprodukte von Mikrooganismen. 78. Isolierung, Identifizierung und Wirkungsweise von Ketomycin ((R)-3-Cyclohexenylglyoxylsäure) und dessen Umwandlungsprodukt 3-Cyclohexenylglycin. Arch Mikrobiol. 1969;67(4):339–356. [PubMed] [Google Scholar]
  5. LENNARZ W. J. A long-chain fatty acid acyl-coA synthetase in Bacillus megaterium. Biochim Biophys Acta. 1963 Jun 11;73:335–337. doi: 10.1016/0006-3002(63)90320-2. [DOI] [PubMed] [Google Scholar]
  6. Machtiger N. A., Fox C. F. Biochemistry of bacterial membranes. Annu Rev Biochem. 1973;42:575–600. doi: 10.1146/annurev.bi.42.070173.003043. [DOI] [PubMed] [Google Scholar]
  7. Seelig J. Motion of spin labeled fatty acids in membrane structures. Biomembranes. 1972;3:267–279. doi: 10.1007/978-1-4684-0961-1_18. [DOI] [PubMed] [Google Scholar]
  8. Silbert D. F. Genetic modification of membrane lipid. Annu Rev Biochem. 1975;44:315–339. doi: 10.1146/annurev.bi.44.070175.001531. [DOI] [PubMed] [Google Scholar]
  9. Willecke K., Pardee A. B. Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase. J Biol Chem. 1971 Sep 10;246(17):5264–5272. [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES