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. 2008 Jan 10;149(5):2283–2292. doi: 10.1210/en.2007-1478

Figure 6.

Figure 6

Dark-field photomicrographs showing CRH mRNA signal in the PVN in icv Veh (15% DMSO)-treated animals receiving an ip injection of saline (Sal) (A) or LPS (B). The icv administration of the MAPK inhibitor, PD98059, has no effect on CRH mRNA expression in saline-treated control animals (C) but diminishes the CRH mRNA response after LPS administration (D). E, Semiquantitative image analysis of integrated density units representing CRH mRNA signal in the PVN. *, P < 0.05 compared with Veh/saline, PD98059/saline, and PD98059/LPS groups. Scale bar, 200 μm. III, Third ventricle.