CHEMISTRY, BIOCHEMISTRY. For the article “6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases,” by Edgar R. Wood, Lisa M. Shewchuk, Byron Ellis, Perry Brignola, Ronald L. Brashear, Thomas R. Caferro, Scott H. Dickerson, Hamilton D. Dickson, Kelly H. Donaldson, Michael Gaul, Robert J. Griffin, Anne M. Hassell, Barry Keith, Robert Mullin, Kimberly G. Petrov, Michael J. Reno, David W. Rusnak, Sarva M. Tadepalli, John C. Ulrich, Craig D. Wagner, Dana E. Vanderwall, Alex G. Waterson, Jon D. Williams, Wendy L. White, and David E. Uehling, which appeared in issue 8, February 26, 2008, of Proc Natl Acad Sci USA (105:2773–2778; first published February 19, 2008; 10.1073/pnas.0708281105), the authors note that, in Fig. 3B, a green block obscures the ligand. The corrected figure and its legend appear below.
Fig. 3.
X-ray crystal structure of thienopyrimidine 6 in ErbB-4. (A) Overlay of the ErbB-4 complexed with 6 (green) and EGFR complexed with lapatinib (yellow). (B) Overlay of the active sites of ErbB-4 (green) and EGFR (yellow). The covalent bond between ErbB-4 and 6 is shown as a dotted green line. The location of a hydrogen bond between the pyrimidine N1 of 6 and the hinge region of ErbB-4 is shown by a dashed line. (C) Omit map density for the ErbB-4 inhibitor complex contoured at 1 sigma.