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. 1976 May;126(2):758–770. doi: 10.1128/jb.126.2.758-770.1976

cheA, cheB, and cheC genes of Escherichia coli and their role in chemotaxis.

J S Parkinson
PMCID: PMC233211  PMID: 770453

Abstract

Motile but generally nonchemotatic (che) mutants of Escherichia coli were isolated by a simple screening method. A total of 172 independent mutants were examined, and four genes were defined on the basis of mapping and complemenvestigated by determining their null phenotypes with nonsense or bacteriophage Mu-induced mutations. The cheA and cheB products were essential in producing changes of swimming direction and flagellar rotation. The checC product appeared to be an essential component of the flagellum; however, specific mutational alterations of this component allowed flagellar assembly but prevented directional changes in swimming. Since some cheB mutants changed directions incessantly, this gene product may also serve to control the direction of flagellar rotation in response to chemoreceptor signals. Thus most or all of the common elements in the signalling process were involved in the generation and regulation of changes in the direction of flagellar rotation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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