Original citation: J. Clin. Invest. 116:2739-2747 (2006). doi:10.1172/JCI27798.
Citation for this erratum: J. Clin. Invest. 118:1974 (2008). doi:10.1172/JCI27798C1.
The Trypanosoma species used in this study included a clinically relevant human CSF isolate and bloodstream form (BSF) from a patient with sleeping sickness. A cloned derivative from this parasite termed “IL1852” was originally identified as a T.b. gambiense and was denoted accordingly in the manuscript.
However, the authors recently discovered that IL1852 contains the SRA gene, a characteristic only encountered in T.b. rhodesiense (1). Therefore, because ILRI T.b. gambiense IL2343, a clone derivative of STIB386AA that was derived from TH144/78E(020), was later reclassified as a T.b. rhodesiense (2), the authors have reclassified IL1852 as a T.b. rhodesiense to maintain accuracy.
While the reclassification affects certain aspects of the conclusions of this work, it does not invalidate the key finding of a difference in the BBB traversal between human and animal trypanosomes that correlates with the greater incidence of CNS infection in human compared with animal parasites.
References
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