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. 1977 Apr;130(1):187–191. doi: 10.1128/jb.130.1.187-191.1977

Repair of hydrogen peroxide-induced single-strand breaks in Escherichia coli deoxyribonucleic acid.

H N Ananthaswamy, A Eisenstark
PMCID: PMC235192  PMID: 323227

Abstract

Near-ultraviolet (300 to 400 nm) irradiation of L-tryptophan yielded H2O2 (a toxic photoproduct) that was selectively lethal for rec and polA1 Escherichia coli mutants. H2O2 treatment of cells resulted in the induction of single-strand deoxyribonucleic acid breaks. These breaks were repaired to only a small extent in polA1, recA recB, and recA mutants, but were efficiently repaired in wild-type strains. We conclude that H2O2 deoxyribonucleic acid lesions require both the polA+ and recA+ pathways for repair.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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