Abstract
Small amounts of free mycolic acids and trehalose dimycolate that are rapidly formed by Mycobacterium tuberculosis H37Ra are probably derived from mycolyl acetyl trehalose and transferred to the cell wall. However, the transfer of mycolic acids from mycolyl acetyl trehalose to the cell wall still appears to be the more prominent route.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLOCH H. Studies on the virulence of tubercle bacilli; isolation and biological properties of a constituent of virulent organisms. J Exp Med. 1950 Feb;91(2):197-218, pl. doi: 10.1084/jem.91.2.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takayama K., Armstrong E. L. Isolation, characterization, and function of 6-mycolyl-6'-acetyltrehalose in the H37Ra strain of Myocobacterium tuberculosis. Biochemistry. 1976 Jan 27;15(2):441–447. doi: 10.1021/bi00647a032. [DOI] [PubMed] [Google Scholar]
- Takayama K., Schnoes H. K., Armstrong E. L., Boyle R. W. Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis. J Lipid Res. 1975 Jul;16(4):308–317. [PubMed] [Google Scholar]
- Takayama K. Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria. Ann N Y Acad Sci. 1974 May 10;235(0):426–438. doi: 10.1111/j.1749-6632.1974.tb43281.x. [DOI] [PubMed] [Google Scholar]
- Wang L., Takayama K. Relationship between the uptake of isoniazid and its action on in vivo mycolic acid synthesis in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1972 Dec;2(6):438–441. doi: 10.1128/aac.2.6.438. [DOI] [PMC free article] [PubMed] [Google Scholar]