Abstract
A mutant of Escherichia coli with a delayed relaxed phenotype very similar to that of a previously described relB mutant has been obtained using a new selection procedure. The mutation giving rise to this phenotype has been shown to map at 34.5 min and to be 12% cotransducible with man. It is recessive, revertible, and most likely an allele of the relB gene.
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Selected References
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- ALFOELDI L., STENT G. S., HOOGS M., HILL R. PHYSIOLOGICAL EFFECTS OF THE RNA CONTROL (RC) GENE IN E. COLI. Z Vererbungsl. 1963 Nov 21;94:285–302. doi: 10.1007/BF00894773. [DOI] [PubMed] [Google Scholar]
- Bachmann B. J., Low K. B., Taylor A. L. Recalibrated linkage map of Escherichia coli K-12. Bacteriol Rev. 1976 Mar;40(1):116–167. doi: 10.1128/br.40.1.116-167.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cashel M., Gallant J. Two compounds implicated in the function of the RC gene of Escherichia coli. Nature. 1969 Mar 1;221(5183):838–841. doi: 10.1038/221838a0. [DOI] [PubMed] [Google Scholar]
- Cashel M. Regulation of bacterial ppGpp and pppGpp. Annu Rev Microbiol. 1975;29:301–318. doi: 10.1146/annurev.mi.29.100175.001505. [DOI] [PubMed] [Google Scholar]
- Edlin G., Maaloe O. Synthesis and breakdown of messenger RNA without protein synthesis. J Mol Biol. 1966 Feb;15(2):428–434. doi: 10.1016/s0022-2836(66)80118-3. [DOI] [PubMed] [Google Scholar]
- Fiil N. P., Willumsen B. M., Friesen J. D., von Meyenburg K. Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp. Mol Gen Genet. 1977 Jan 7;150(1):87–101. doi: 10.1007/BF02425329. [DOI] [PubMed] [Google Scholar]
- Fiil N. P., von Meyenburg K., Friesen J. D. Accumulation and turnover of guanosine tetraphosphate in Escherichia coli. J Mol Biol. 1972 Nov 28;71(3):769–783. doi: 10.1016/s0022-2836(72)80037-8. [DOI] [PubMed] [Google Scholar]
- Fill N. A functional analysis of the rel gene in Escherichia coli. J Mol Biol. 1969 Oct 28;45(2):195–203. doi: 10.1016/0022-2836(69)90099-0. [DOI] [PubMed] [Google Scholar]
- Friesen J. D., Fiil N. P., Parker J. M., Haseltine W. A. A new relaxed mutant of Escherichia coli with an altered 50S ribosomal subunit. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3465–3469. doi: 10.1073/pnas.71.9.3465. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEAVITT R. I., UMBARGER H. E. Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. J Bacteriol. 1962 Mar;83:624–630. doi: 10.1128/jb.83.3.624-630.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LENNOX E. S. Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955 Jul;1(2):190–206. doi: 10.1016/0042-6822(55)90016-7. [DOI] [PubMed] [Google Scholar]
- Lavallé R. Nouveaux mutants de régulation de la synthèse de l'ARN. Bull Soc Chim Biol (Paris) 1965;47(8):1567–1570. [PubMed] [Google Scholar]
- Martin R. G. Polarity in relaxed strains of Salmonella typhimurium. J Mol Biol. 1968 Jan 14;31(1):127–134. doi: 10.1016/0022-2836(68)90060-0. [DOI] [PubMed] [Google Scholar]
- Parker J., Watson R. J., Friesen J. D. A relaxed mutant with an altered ribosomal protein L11. Mol Gen Genet. 1976 Feb 27;144(1):111–114. doi: 10.1007/BF00277313. [DOI] [PubMed] [Google Scholar]
- STENT G. S., BRENNER S. A genetic locus for the regulation of ribonucleic acid synthesis. Proc Natl Acad Sci U S A. 1961 Dec 15;47:2005–2014. doi: 10.1073/pnas.47.12.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]