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. 1977 Sep;131(3):789–794. doi: 10.1128/jb.131.3.789-794.1977

Metabolism of 6-aminonicotinic acid in Escherichia coli.

J R Cobb, S C Pearcy, R K Gholson
PMCID: PMC235532  PMID: 19420

Abstract

A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide cycle. It is concluded that 6-aminonicotinamide and 6-aminonicotinic acid probably exert at least a portion of their bacteriostatic effects by being metabolized, by the enzymes of the pyridine nucleotide cycle, to 6-aminonicotinamide adenine dinucleotide and 6-aminonicotinamide adenine dinucleotide phosphate. These compounds are not electron acceptors and are known inhibitors of some pyridine nucleotide-linked dehydrogenases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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