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. 1975 Jul;123(1):272–277. doi: 10.1128/jb.123.1.272-277.1975

Alterations of the rate of movement of deoxyribonucleic acid replication forks.

M L Pato
PMCID: PMC235716  PMID: 1095556

Abstract

Antibiotics that inhibit ribonucleic acid (RNA) or protein synthesis are often used in studies of deoxyribonucleic acid (DNA) synthesis. The experiments presented here demonstrate that the rate of movement of DNA replication forks can be influenced by such antibotics. Addition of either chloramphenicol, which inhibits movement of ribosomes along messenger RNA, or streptolydigin, which inhibits movement of RNA polymerase, leads to a decrease in the rate of fork movement. Rifampin, which inhibits initiation of RNA synthesis, reverses the effects of chloramphenicol or streptolydigin. The slowed movement of DNA replication forks is discussed in terms of obstruction of fork movement by transcription complexes temporarily immobilized on the DNA template.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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