Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1975 Oct;124(1):212–219. doi: 10.1128/jb.124.1.212-219.1975

Inhibition of development in Dictyostelium discoideum by sugars.

H V Rickenberg, H J Rahmsdorf, A Campbell, M J North, J Kwasniak, J M Ashworth
PMCID: PMC235884  PMID: 1236845

Abstract

Sugars such as glucose, maltose, and trehalose, which are metabolized by Dictyostelium discoideum and which enhance vegetative growth, inhibit the development of the slime mold at concentrations which stimulate growth maximally. They block the acquisition of aggregation competence as well as aggregation. The same sugars also inhibit the degradation of preformed glycogen ribonucleic acid, and protein, which is characteristic of development and which occurs when the amoebas are starved by incubation in dilute phosphate buffer.

Full text

PDF
212

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beug H., Katz F. E., Gerisch G. Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum. J Cell Biol. 1973 Mar;56(3):647–658. doi: 10.1083/jcb.56.3.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buettner M. J., Spitz E., Rickenberg H. V. Cyclic adenosine 3',5'-monophosphate in Escherichia coli. J Bacteriol. 1973 Jun;114(3):1068–1073. doi: 10.1128/jb.114.3.1068-1073.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Garrod D. R., Ashworth I. M. Effect of growth conditions on development of the cellular slime mould, Dictyostelium discoideum. J Embryol Exp Morphol. 1972 Oct;28(2):463–479. [PubMed] [Google Scholar]
  4. Gerisch G., Hess B. Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions. Proc Natl Acad Sci U S A. 1974 May;71(5):2118–2122. doi: 10.1073/pnas.71.5.2118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hames B. D., Ashworth J. M. The metabolism of macromolecules during the differentiation of Myxamoebae of the cellular slime mould Dictyostelium discoideum containing different amounts of glycogen. Biochem J. 1974 Aug;142(2):301–315. doi: 10.1042/bj1420301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hames B. D., Weeks G., Ashworth J. M. Glycogen synthetase and the control of glycogen synthesis in the cellular slime mould Dictyostelium discoideum during cell differentiation. Biochem J. 1972 Feb;126(3):627–633. doi: 10.1042/bj1260627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones T. H., Wright B. E. Partial purification and characterization of glycogen phosphorylase from Dictyostelium discoideum. J Bacteriol. 1970 Nov;104(2):754–761. doi: 10.1128/jb.104.2.754-761.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. KRICHEVSKY M. I., WRIGHT B. E. ENVIRONMENTAL CONTROL OF THE COURSE OF DEVELOPMENT IN DICTYOSTELIUM DISCOIDEUM. J Gen Microbiol. 1963 Aug;32:195–207. doi: 10.1099/00221287-32-2-195. [DOI] [PubMed] [Google Scholar]
  9. Konijn T. M., Chang Y. Y., Bonner J. T. Synthesis of cyclic AMP in Dictyostelium discoideum and Polysphondylium pallidum. Nature. 1969 Dec 20;224(5225):1211–1212. doi: 10.1038/2241211a0. [DOI] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Lee K. C. Permeability of Dictyostelium discoideum towards amino acids and inulin: a possible relationship between initiation of differentiation and loss of "pool" metabolites. J Gen Microbiol. 1972 Oct;72(3):457–471. doi: 10.1099/00221287-72-3-457. [DOI] [PubMed] [Google Scholar]
  12. MAKMAN R. S., SUTHERLAND E. W. ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI. J Biol Chem. 1965 Mar;240:1309–1314. [PubMed] [Google Scholar]
  13. Maeda Y., Maeda M. Heterogeneity of the cell population of the cellular slime mold Dictyostelium discoideum before aggregation, and its relation to the subsequent locations of the cells. Exp Cell Res. 1974 Mar 15;84(1):88–94. doi: 10.1016/0014-4827(74)90383-8. [DOI] [PubMed] [Google Scholar]
  14. Malkinson A. M., Ashworth J. M. Adenosine 3':5'-cyclic monophosphate concentrations and phosphodiesterase activities during axenic growth and differentiation of cells of the cellular slime mould Dictyostelium discoideum. Biochem J. 1973 May;134(1):311–319. doi: 10.1042/bj1340311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pan P., Bonner J. T., Wedner H. Y., Parker C. W. Immunofluorescence evidence for the distribution of cyclic AMP in cells and cell masses of the cellular slime molds. Proc Natl Acad Sci U S A. 1974 May;71(5):1623–1625. doi: 10.1073/pnas.71.5.1623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rickenberg H. V. Cyclic AMP in prokaryotes. Annu Rev Microbiol. 1974;28(0):353–369. doi: 10.1146/annurev.mi.28.100174.002033. [DOI] [PubMed] [Google Scholar]
  17. Rosness P. A., Gustafson G., Wright B. E. Effects of adenosine 3',5'-monophosphate and adenosine 5'-monophosphate on glycogen degradation and synthesis in Dictyostelium discoideum. J Bacteriol. 1971 Dec;108(3):1329–1337. doi: 10.1128/jb.108.3.1329-1337.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Van Handel E. Estimation of glycogen in small amounts of tissue. Anal Biochem. 1965 May;11(2):256–265. doi: 10.1016/0003-2697(65)90013-8. [DOI] [PubMed] [Google Scholar]
  19. Watts D. J., Ashworth J. M. Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem J. 1970 Sep;119(2):171–174. doi: 10.1042/bj1190171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wiener E., Ashworth J. M. The isolation and characterization of lysosomal particles from myxamoebae of the cellular slime mould Dictyostelium discoideum. Biochem J. 1970 Jul;118(3):505–512. doi: 10.1042/bj1180505. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES