Abstract
A case is presented of a young competitive body-builder who abused anabolic steroid drugs and developed profound symptomatic hypogonadotrophic hypogonadism. With the help of prescribed testosterone (Sustanon) he stopped taking anabolic drugs, and later stopped Sustanon also. Hypogonadism returned, but was successfully treated with weekly injections of human chorionic gonadotropin for three months. Testicular function remained normal thereafter on no treatment. The use of human chorionic gonadotropin should be considered in prolonged hypogonadotrophic hypogonadism due to anabolic steroid abuse.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bagatell C. J., Bremner W. J. Androgens in men--uses and abuses. N Engl J Med. 1996 Mar 14;334(11):707–714. doi: 10.1056/NEJM199603143341107. [DOI] [PubMed] [Google Scholar]
- Buckley W. E., Yesalis C. E., 3rd, Friedl K. E., Anderson W. A., Streit A. L., Wright J. E. Estimated prevalence of anabolic steroid use among male high school seniors. JAMA. 1988 Dec 16;260(23):3441–3445. [PubMed] [Google Scholar]
- Jarow J. P., Lipshultz L. I. Anabolic steroid-induced hypogonadotropic hypogonadism. Am J Sports Med. 1990 Jul-Aug;18(4):429–431. doi: 10.1177/036354659001800417. [DOI] [PubMed] [Google Scholar]
- Lamb D. R. Anabolic steroids in athletics: how well do they work and how dangerous are they? Am J Sports Med. 1984 Jan-Feb;12(1):31–38. doi: 10.1177/036354658401200105. [DOI] [PubMed] [Google Scholar]
- Martikainen H., Alén M., Rahkila P., Vihko R. Testicular responsiveness to human chorionic gonadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes. J Steroid Biochem. 1986 Jul;25(1):109–112. doi: 10.1016/0022-4731(86)90288-8. [DOI] [PubMed] [Google Scholar]
- McKillop G. Drug abuse in body builders in the West of Scotland. Scott Med J. 1987 Apr;32(2):39–41. doi: 10.1177/003693308703200204. [DOI] [PubMed] [Google Scholar]
- Perry H. M., Littlepage B. N. Misusing anabolic drugs. BMJ. 1992 Nov 21;305(6864):1241–1242. doi: 10.1136/bmj.305.6864.1241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Su T. P., Pagliaro M., Schmidt P. J., Pickar D., Wolkowitz O., Rubinow D. R. Neuropsychiatric effects of anabolic steroids in male normal volunteers. JAMA. 1993 Jun 2;269(21):2760–2764. [PubMed] [Google Scholar]
- Wilson J. D. Androgen abuse by athletes. Endocr Rev. 1988 May;9(2):181–199. doi: 10.1210/edrv-9-2-181. [DOI] [PubMed] [Google Scholar]
- Wu F. C. Testicular steroidogenesis and androgen use and abuse. Baillieres Clin Endocrinol Metab. 1992 Apr;6(2):373–403. doi: 10.1016/s0950-351x(05)80155-7. [DOI] [PubMed] [Google Scholar]