Abstract
We describe a 77-year-old woman who developed fatigue, fever, a maculopapular rash and severe cholestatic hepatitis two weeks after receiving cloxacillin and ofloxacin.
Keywords: hepatitis, cloxacillin, ofloxacin
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aderka D., Livni E., Salamon F., Weinberger A., Pinkhas J. Use of macrophage inhibition factor and mast-cell degranulation tests for diagnosis of cloxacillin-induced cholestasis. Am J Gastroenterol. 1986 Nov;81(11):1084–1086. [PubMed] [Google Scholar]
- Enat R., Pollack S., Ben-Arieh Y., Livni E., Barzilai D. Cholestatic jaundice caused by cloxacillin: macrophage inhibition factor test in preventing rechallenge with hepatotoxic drugs. Br Med J. 1980 Apr 5;280(6219):982–983. doi: 10.1136/bmj.280.6219.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kaplowitz N., Aw T. Y., Simon F. R., Stolz A. Drug-induced hepatotoxicity. Ann Intern Med. 1986 Jun;104(6):826–839. doi: 10.7326/0003-4819-104-6-826. [DOI] [PubMed] [Google Scholar]
- Koek G. H., Stricker B. H., Blok A. P., Schalm S. W., Desmet V. J. Flucloxacillin-associated hepatic injury. Liver. 1994 Oct;14(5):225–229. doi: 10.1111/j.1600-0676.1994.tb00079.x. [DOI] [PubMed] [Google Scholar]
- Konikoff F., Alcalay J., Halevy J. Cloxacillin-induced cholestatic jaundice. Am J Gastroenterol. 1986 Nov;81(11):1082–1083. [PubMed] [Google Scholar]
- Lotric S., Lejko-Zupanc T., Jereb M. Cloxacillin-induced cholestasis. Clin Infect Dis. 1994 Nov;19(5):981–982. doi: 10.1093/clinids/19.5.981. [DOI] [PubMed] [Google Scholar]
- López-Navidad A., Domingo P., Cadafalch J., Farrerons J. Norfloxacin-induced hepatotoxicity. J Hepatol. 1990 Sep;11(2):277–278. doi: 10.1016/0168-8278(90)90125-b. [DOI] [PubMed] [Google Scholar]
- Miros M., Kerlin P., Walker N., Harris O. Flucloxacillin induced delayed cholestatic hepatitis. Aust N Z J Med. 1990 Jun;20(3):251–253. doi: 10.1111/j.1445-5994.1990.tb01032.x. [DOI] [PubMed] [Google Scholar]
- Pascual J., Orofino L., Marcén R., Quereda C., Ortuño J. Cloxacillin-induced cholestasis in a renal allograft patient with chronic hepatitis. Am J Gastroenterol. 1990 Mar;85(3):335–336. [PubMed] [Google Scholar]
- Turner I. B., Eckstein R. P., Riley J. W., Lunzer M. R. Prolonged hepatic cholestasis after flucloxacillin therapy. Med J Aust. 1989 Dec 4;151(11-12):701–705. doi: 10.5694/j.1326-5377.1989.tb139652.x. [DOI] [PubMed] [Google Scholar]
