Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1998 Jan;74(867):59–60. doi: 10.1136/pgmj.74.867.59

Severe cholestatic hepatitis following cloxacillin treatment

Sorel Goland, Stephen DH Malnick, Raia Gratz, Edith Feldberg, David Geltner, Zev M Sthoeger
PMCID: PMC2360792  PMID: 9538497

Abstract

We describe a 77-year-old woman who developed fatigue, fever, a maculopapular rash and severe cholestatic hepatitis two weeks after receiving cloxacillin and ofloxacin.

Keywords: hepatitis, cloxacillin, ofloxacin

Full text

PDF
59

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aderka D., Livni E., Salamon F., Weinberger A., Pinkhas J. Use of macrophage inhibition factor and mast-cell degranulation tests for diagnosis of cloxacillin-induced cholestasis. Am J Gastroenterol. 1986 Nov;81(11):1084–1086. [PubMed] [Google Scholar]
  2. Enat R., Pollack S., Ben-Arieh Y., Livni E., Barzilai D. Cholestatic jaundice caused by cloxacillin: macrophage inhibition factor test in preventing rechallenge with hepatotoxic drugs. Br Med J. 1980 Apr 5;280(6219):982–983. doi: 10.1136/bmj.280.6219.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kaplowitz N., Aw T. Y., Simon F. R., Stolz A. Drug-induced hepatotoxicity. Ann Intern Med. 1986 Jun;104(6):826–839. doi: 10.7326/0003-4819-104-6-826. [DOI] [PubMed] [Google Scholar]
  4. Koek G. H., Stricker B. H., Blok A. P., Schalm S. W., Desmet V. J. Flucloxacillin-associated hepatic injury. Liver. 1994 Oct;14(5):225–229. doi: 10.1111/j.1600-0676.1994.tb00079.x. [DOI] [PubMed] [Google Scholar]
  5. Konikoff F., Alcalay J., Halevy J. Cloxacillin-induced cholestatic jaundice. Am J Gastroenterol. 1986 Nov;81(11):1082–1083. [PubMed] [Google Scholar]
  6. Lotric S., Lejko-Zupanc T., Jereb M. Cloxacillin-induced cholestasis. Clin Infect Dis. 1994 Nov;19(5):981–982. doi: 10.1093/clinids/19.5.981. [DOI] [PubMed] [Google Scholar]
  7. López-Navidad A., Domingo P., Cadafalch J., Farrerons J. Norfloxacin-induced hepatotoxicity. J Hepatol. 1990 Sep;11(2):277–278. doi: 10.1016/0168-8278(90)90125-b. [DOI] [PubMed] [Google Scholar]
  8. Miros M., Kerlin P., Walker N., Harris O. Flucloxacillin induced delayed cholestatic hepatitis. Aust N Z J Med. 1990 Jun;20(3):251–253. doi: 10.1111/j.1445-5994.1990.tb01032.x. [DOI] [PubMed] [Google Scholar]
  9. Pascual J., Orofino L., Marcén R., Quereda C., Ortuño J. Cloxacillin-induced cholestasis in a renal allograft patient with chronic hepatitis. Am J Gastroenterol. 1990 Mar;85(3):335–336. [PubMed] [Google Scholar]
  10. Turner I. B., Eckstein R. P., Riley J. W., Lunzer M. R. Prolonged hepatic cholestasis after flucloxacillin therapy. Med J Aust. 1989 Dec 4;151(11-12):701–705. doi: 10.5694/j.1326-5377.1989.tb139652.x. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES