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. 1999 Mar;79(7-8):1308–1314. doi: 10.1038/sj.bjc.6690210

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

S M Enger 1,2, R K Ross 2, A Paganini-Hill 2, M P Longnecker 3, L Bernstein 2
PMCID: PMC2362214  PMID: 10098777

Abstract

We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign

Keywords: alcohol, oestrogen receptors, progesterone receptors, breast neoplasms, epidemiology

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Selected References

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  1. Bernstein L., Henderson B. E., Hanisch R., Sullivan-Halley J., Ross R. K. Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst. 1994 Sep 21;86(18):1403–1408. doi: 10.1093/jnci/86.18.1403. [DOI] [PubMed] [Google Scholar]
  2. Cooper J. A., Rohan T. E., Cant E. L., Horsfall D. J., Tilley W. D. Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study. Br J Cancer. 1989 Jan;59(1):119–125. doi: 10.1038/bjc.1989.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gamulin S., Romić-Stojković R. Oestrogen and progesterone receptors in primary breast cancer: a population study. Eur J Cancer. 1991;27(4):491–495. doi: 10.1016/0277-5379(91)90393-r. [DOI] [PubMed] [Google Scholar]
  4. Gapstur S. M., Potter J. D., Drinkard C., Folsom A. R. Synergistic effect between alcohol and estrogen replacement therapy on risk of breast cancer differs by estrogen/progesterone receptor status in the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):313–318. [PubMed] [Google Scholar]
  5. Gavaler J. S., Deal S. R., Van Thiel D. H., Arria A., Allan M. J. Alcohol and estrogen levels in postmenopausal women: the spectrum of effect. Alcohol Clin Exp Res. 1993 Aug;17(4):786–790. doi: 10.1111/j.1530-0277.1993.tb00842.x. [DOI] [PubMed] [Google Scholar]
  6. Habel L. A., Stanford J. L. Hormone receptors and breast cancer. Epidemiol Rev. 1993;15(1):209–219. doi: 10.1093/oxfordjournals.epirev.a036107. [DOI] [PubMed] [Google Scholar]
  7. Hankinson S. E., Willett W. C., Manson J. E., Hunter D. J., Colditz G. A., Stampfer M. J., Longcope C., Speizer F. E. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst. 1995 Sep 6;87(17):1297–1302. doi: 10.1093/jnci/87.17.1297. [DOI] [PubMed] [Google Scholar]
  8. Holm L. E., Callmer E., Hjalmar M. L., Lidbrink E., Nilsson B., Skoog L. Dietary habits and prognostic factors in breast cancer. J Natl Cancer Inst. 1989 Aug 16;81(16):1218–1223. doi: 10.1093/jnci/81.16.1218. [DOI] [PubMed] [Google Scholar]
  9. Katsouyanni K., Boyle P., Trichopoulos D. Diet and urine estrogens among postmenopausal women. Oncology. 1991;48(6):490–494. doi: 10.1159/000226987. [DOI] [PubMed] [Google Scholar]
  10. Longnecker M. P., Paganini-Hill A., Ross R. K. Lifetime alcohol consumption and breast cancer risk among postmenopausal women in Los Angeles. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov;4(7):721–725. [PubMed] [Google Scholar]
  11. McGuire W. L. Prognostic factors in primary breast cancer. Cancer Surv. 1986;5(3):527–536. [PubMed] [Google Scholar]
  12. McTiernan A., Thomas D. B., Johnson L. K., Roseman D. Risk factors for estrogen receptor-rich and estrogen receptor-poor breast cancers. J Natl Cancer Inst. 1986 Oct;77(4):849–854. [PubMed] [Google Scholar]
  13. Mendelson J. H., Lukas S. E., Mello N. K., Amass L., Ellingboe J., Skupny A. Acute alcohol effects on plasma estradiol levels in women. Psychopharmacology (Berl) 1988;94(4):464–467. doi: 10.1007/BF00212838. [DOI] [PubMed] [Google Scholar]
  14. Mendelson J. H., Mello N. K., Cristofaro P., Ellingboe J., Skupny A., Palmieri S. L., Benedikt R., Schiff I. Alcohol effects on naloxone-stimulated luteinizing hormone, prolactin and estradiol in women. J Stud Alcohol. 1987 Jul;48(4):287–294. doi: 10.15288/jsa.1987.48.287. [DOI] [PubMed] [Google Scholar]
  15. Mendelson J. H., Mello N. K., Teoh S. K., Ellingboe J. Alcohol effects on luteinizing hormone releasing hormone-stimulated anterior pituitary and gonadal hormones in women. J Pharmacol Exp Ther. 1989 Sep;250(3):902–909. [PubMed] [Google Scholar]
  16. Mobbs B. G., Fish E. B., Pritchard K. I., Oldfield G., Hanna W. H. Estrogen and progesterone receptor content of primary and secondary breast carcinoma: influence of time and treatment. Eur J Cancer Clin Oncol. 1987 Jun;23(6):819–826. doi: 10.1016/0277-5379(87)90285-9. [DOI] [PubMed] [Google Scholar]
  17. Nasca P. C., Liu S., Baptiste M. S., Kwon C. S., Jacobson H., Metzger B. B. Alcohol consumption and breast cancer: estrogen receptor status and histology. Am J Epidemiol. 1994 Dec 1;140(11):980–988. doi: 10.1093/oxfordjournals.aje.a117205. [DOI] [PubMed] [Google Scholar]
  18. Potter J. D., Cerhan J. R., Sellers T. A., McGovern P. G., Drinkard C., Kushi L. R., Folsom A. R. Progesterone and estrogen receptors and mammary neoplasia in the Iowa Women's Health Study: how many kinds of breast cancer are there? Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):319–326. [PubMed] [Google Scholar]
  19. Raabe N. K., Hagen S., Haug E., Fossaa S. D. Hormone receptor measurements and survival in 1335 consecutive patients with primary invasive breast carcinoma. Int J Oncol. 1998 May;12(5):1091–1096. doi: 10.3892/ijo.12.5.1091. [DOI] [PubMed] [Google Scholar]
  20. Reichman M. E., Judd J. T., Longcope C., Schatzkin A., Clevidence B. A., Nair P. P., Campbell W. S., Taylor P. R. Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst. 1993 May 5;85(9):722–727. doi: 10.1093/jnci/85.9.722. [DOI] [PubMed] [Google Scholar]
  21. Ruder A. M., Lubin F., Wax Y., Geier A., Alfundary E., Chetrit A. Estrogen and progesterone receptors in breast cancer patients. Epidemiologic characteristics and survival differences. Cancer. 1989 Jul 1;64(1):196–202. doi: 10.1002/1097-0142(19890701)64:1<196::aid-cncr2820640134>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  22. Tani E., Nordenskjöld B., Humla S., Skoog L. Estrogen receptor content in primary breast carcinomas and their metastases. Anticancer Res. 1988 Jan-Feb;8(1):169–171. [PubMed] [Google Scholar]
  23. Teoh S. K., Mendelson J. H., Mello N. K., Skupny A. Alcohol effects on naltrexone-induced stimulation of pituitary, adrenal, and gonadal hormones during the early follicular phase of the menstrual cycle. J Clin Endocrinol Metab. 1988 Jun;66(6):1181–1186. doi: 10.1210/jcem-66-6-1181. [DOI] [PubMed] [Google Scholar]
  24. Toniolo P. G., Levitz M., Zeleniuch-Jacquotte A., Banerjee S., Koenig K. L., Shore R. E., Strax P., Pasternack B. S. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst. 1995 Feb 1;87(3):190–197. doi: 10.1093/jnci/87.3.190. [DOI] [PubMed] [Google Scholar]
  25. Yoo K. Y., Tajima K., Miura S., Takeuchi T., Hirose K., Risch H., Dubrow R. Breast cancer risk factors according to combined estrogen and progesterone receptor status: a case-control analysis. Am J Epidemiol. 1997 Aug 15;146(4):307–314. doi: 10.1093/oxfordjournals.aje.a009271. [DOI] [PubMed] [Google Scholar]
  26. Zeleniuch-Jacquotte A., Toniolo P., Levitz M., Shore R. E., Koenig K. L., Banerjee S., Strax P., Pasternack B. S. Endogenous estrogens and risk of breast cancer by estrogen receptor status: a prospective study in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):857–860. [PubMed] [Google Scholar]

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