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. 1999 May;80(5-6):850–854. doi: 10.1038/sj.bjc.6690431

Deletion mapping of chromosome 16q in hepatocellular carcinoma

Z Piao 1, C Park 1, J J Kim 1, H Kim 1
PMCID: PMC2362275  PMID: 10360665

Abstract

Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among the 35 cases with AI, 21 cases showed multiple AI, suggesting the wide scope of deletion on the long arm of chromosome 16, and the remaining 14 cases showed partial AI. Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm. These included the D16S3106 locus and D16S498 locus. In conclusion, we have demonstrated frequent AI on 16q in HCCs and identified two loci with frequent AI, which may harbour new tumour suppressor genes. © 1999 Cancer Research Campaign

Keywords: hepatocellular carcinoma, allelic imbalance, tumour suppressor genes

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Selected References

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