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. 1999 May;80(5-6):879–882. doi: 10.1038/sj.bjc.6690435

European multicenter study on LOH of APOC3 at 11q23 in 766 breast cancer patients: relation to clinical variables

V Launonen 1, K Laake 4, P Huusko 1, D Niederacher 5, M W Beckmann 5, R B Barkardottir 6, E K Geirsdottir 6, J Gudmundsson 6, P Rio 7, Y-J Bignon 8, S Seitz 9, S Scherneck 9, I Bièche 10, M-H Champème 10, D Birnbaum 11, G White 12, J Varley 12, M Sztán 13, E Olah 13, A Osorio 14, J Benitez 14, N Spurr 15,1, N Velikonja 16, B Peterlin 16, Å Borg 17, A-M Cleton-Jansen 18, P Devilee 18, R Bloigu 2, R Lidereau 10, A-L Børresen-Dale 4, R Winqvist 1,3; the Breast Cancer Somatic Genetics Consortium
PMCID: PMC2362288  PMID: 10360669

Abstract

High frequencies of loss of heterozygosity (LOH) in chromosome 11q22-qter have been observed in various malignancies, including breast cancer. Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660–2664) have indicated that a survival factor gene is located in band 11q23, and that the highly informative microsatellite polymorphism at the APOC3 locus would be a suitable tool to perform more extensive LOH studies. In this European multicentre study, we have examined the occurrence of APOC3 LOH and evaluated the effect of LOH of this chromosomal subregion on the clinical behaviour of the disease in a cohort of 766 breast cancer patients in more detail. LOH for APOC3 was found in 42% of the studied tumours, but it was not found to be significantly associated with any of the studied clinical variables, including cancer-specific survival time or survival time after recurrent/metastatic disease. According to the present findings, the putative survival factor gene on 11q23 is not located close enough to the APOC3 gene, but apparently at a more proximal location. © 1999 Cancer Research Campaign

Keywords: breast cancer, chromosome 11q23, loss of heterozygosity

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arai Y., Hosoda F., Nakayama K., Ohki M. A yeast artificial chromosome contig and NotI restriction map that spans the tumor suppressor gene(s) locus, 11q22.2-q23.3. Genomics. 1996 Jul 1;35(1):196–206. doi: 10.1006/geno.1996.0339. [DOI] [PubMed] [Google Scholar]
  2. Bhattacharya S., Wilson T. M., Wojciechowski A. P., Volpe C. P., Scott J. Hypervariable polymorphism in the APOC3 gene. Nucleic Acids Res. 1991 Sep 11;19(17):4799–4799. doi: 10.1093/nar/19.17.4799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bièche I., Lidereau R. Genetic alterations in breast cancer. Genes Chromosomes Cancer. 1995 Dec;14(4):227–251. doi: 10.1002/gcc.2870140402. [DOI] [PubMed] [Google Scholar]
  4. Furnari B., Rhind N., Russell P. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science. 1997 Sep 5;277(5331):1495–1497. doi: 10.1126/science.277.5331.1495. [DOI] [PubMed] [Google Scholar]
  5. Gabra H., Watson J. E., Taylor K. J., Mackay J., Leonard R. C., Steel C. M., Porteous D. J., Smyth J. F. Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis. Cancer Res. 1996 Mar 1;56(5):950–954. [PubMed] [Google Scholar]
  6. Gudmundsson J., Barkardottir R. B., Eiriksdottir G., Baldursson T., Arason A., Egilsson V., Ingvarsson S. Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations. Br J Cancer. 1995 Sep;72(3):696–701. doi: 10.1038/bjc.1995.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hampton G. M., Mannermaa A., Winqvist R., Alavaikko M., Blanco G., Taskinen P. J., Kiviniemi H., Newsham I., Cavenee W. K., Evans G. A. Loss of heterozygosity in sporadic human breast carcinoma: a common region between 11q22 and 11q23.3. Cancer Res. 1994 Sep 1;54(17):4586–4589. [PubMed] [Google Scholar]
  8. Herbst R. A., Larson A., Weiss J., Cavenee W. K., Hampton G. M., Arden K. C. A defined region of loss of heterozygosity at 11q23 in cutaneous malignant melanoma. Cancer Res. 1995 Jun 15;55(12):2494–2496. [PubMed] [Google Scholar]
  9. Hui A. B., Lo K. W., Leung S. F., Choi P. H., Fong Y., Lee J. C., Huang D. P. Loss of heterozygosity on the long arm of chromosome 11 in nasopharyngeal carcinoma. Cancer Res. 1996 Jul 15;56(14):3225–3229. [PubMed] [Google Scholar]
  10. Kerangueven F., Eisinger F., Noguchi T., Allione F., Wargniez V., Eng C., Padberg G., Theillet C., Jacquemier J., Longy M. Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions. Oncogene. 1997 Jan 23;14(3):339–347. doi: 10.1038/sj.onc.1200818. [DOI] [PubMed] [Google Scholar]
  11. Laake K., Odegård A., Andersen T. I., Bukholm I. K., Kåresen R., Nesland J. M., Ottestad L., Shiloh Y., Børresen-Dale A. L. Loss of heterozygosity at 11q23.1 in breast carcinomas: indication for involvement of a gene distal and close to ATM. Genes Chromosomes Cancer. 1997 Mar;18(3):175–180. [PubMed] [Google Scholar]
  12. Lindblom A., Sandelin K., Iselius L., Dumanski J., White I., Nordenskjöld M., Larsson C. Predisposition for breast cancer in carriers of constitutional translocation 11q;22q. Am J Hum Genet. 1994 May;54(5):871–876. [PMC free article] [PubMed] [Google Scholar]
  13. Monaco C., Negrini M., Sozzi G., Veronese M. L., Vorechovsky I., Godwin A. K., Croce C. M. Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23. Genomics. 1997 Dec 1;46(2):217–222. doi: 10.1006/geno.1997.5036. [DOI] [PubMed] [Google Scholar]
  14. Negrini M., Rasio D., Hampton G. M., Sabbioni S., Rattan S., Carter S. L., Rosenberg A. L., Schwartz G. F., Shiloh Y., Cavenee W. K. Definition and refinement of chromosome 11 regions of loss of heterozygosity in breast cancer: identification of a new region at 11q23.3. Cancer Res. 1995 Jul 15;55(14):3003–3007. [PubMed] [Google Scholar]
  15. Negrini M., Sabbioni S., Possati L., Rattan S., Corallini A., Barbanti-Brodano G., Croce C. M. Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11. Cancer Res. 1994 Mar 1;54(5):1331–1336. [PubMed] [Google Scholar]
  16. Phillips K. K., Welch D. R., Miele M. E., Lee J. H., Wei L. L., Weissman B. E. Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11. Cancer Res. 1996 Mar 15;56(6):1222–1227. [PubMed] [Google Scholar]
  17. Rasio D., Negrini M., Manenti G., Dragani T. A., Croce C. M. Loss of heterozygosity at chromosome 11q in lung adenocarcinoma: identification of three independent regions. Cancer Res. 1995 Sep 15;55(18):3988–3991. [PubMed] [Google Scholar]
  18. Robertson G., Coleman A., Lugo T. G. A malignant melanoma tumor suppressor on human chromosome 11. Cancer Res. 1996 Oct 1;56(19):4487–4492. [PubMed] [Google Scholar]
  19. Sanchez Y., Wong C., Thoma R. S., Richman R., Wu Z., Piwnica-Worms H., Elledge S. J. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 5;277(5331):1497–1501. doi: 10.1126/science.277.5331.1497. [DOI] [PubMed] [Google Scholar]
  20. Savitsky K., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D. A., Smith S., Uziel T., Sfez S. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science. 1995 Jun 23;268(5218):1749–1753. doi: 10.1126/science.7792600. [DOI] [PubMed] [Google Scholar]
  21. Savitsky K., Ziv Y., Bar-Shira A., Gilad S., Tagle D. A., Smith S., Uziel T., Sfez S., Nahmias J., Sartiel A. A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. Genomics. 1996 Apr 15;33(2):199–206. doi: 10.1006/geno.1996.0184. [DOI] [PubMed] [Google Scholar]
  22. Winqvist R., Hampton G. M., Mannermaa A., Blanco G., Alavaikko M., Kiviniemi H., Taskinen P. J., Evans G. A., Wright F. A., Newsham I. Loss of heterozygosity for chromosome 11 in primary human breast tumors is associated with poor survival after metastasis. Cancer Res. 1995 Jun 15;55(12):2660–2664. [PubMed] [Google Scholar]
  23. Ziemin-van der Poel S., McCabe N. R., Gill H. J., Espinosa R., 3rd, Patel Y., Harden A., Rubinelli P., Smith S. D., LeBeau M. M., Rowley J. D. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10735–10739. doi: 10.1073/pnas.88.23.10735. [DOI] [PMC free article] [PubMed] [Google Scholar]

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