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. 1999 Jun;80(8):1262–1264. doi: 10.1038/sj.bjc.6690495

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

J M Silva 1, G Dominguez 1, M J Villanueva 1, R Gonzalez 1, J M Garcia 1, C Corbacho 1, M Provencio 1, P España 1, F Bonilla 1
PMCID: PMC2362379  PMID: 10376981

Abstract

Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients. © 1999 Cancer Research Campaign

Keywords: p16INK4a gene, DNA methylation, breast cancer, plasma DNA, CpG islands

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Selected References

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