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. 1999 Feb;79(3-4):478–482. doi: 10.1038/sj.bjc.6690074

Use of positron emission tomography in evaluation of brachial plexopathy in breast cancer patients

A Ahmad 1, S Barrington 2, M Maisey 2, R D Rubens 1
PMCID: PMC2362404  PMID: 10027316

Abstract

18-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has previously been used successfully to image primary and metastatic breast cancer. In this pilot study, 19 breast cancer patients with symptoms/signs referrable to the brachial plexus were evaluated with 18FDG-PET. In 11 cases computerized tomography (CT) scanning was also performed. Of the 19 patients referred for PET study, 14 had abnormal uptake of 18FDG in the region of the symptomatic plexus. Four patients had normal PET studies and one had increased FDG uptake in the chest wall that accounted for her axillary pain. CT scans were performed in 9 of the 14 patients who had positive brachial plexus PET studies; six of these were either normal or showed no clear evidence of recurrent disease, while three CTs demonstrated clear brachial plexus involvement. Of two of the four patients with normal PET studies, one has had complete resolution of symptoms untreated while the other was found to have cervical disc herniation on magnetic resonance imaging (MRI) scan. The remaining two patients almost certainly had radiation-induced plexopathy and had normal CT, MRI and PET study. These data suggest that 18FDG-PET scanning is a useful tool in evaluation of patients with suspected metastatic plexopathy, particularly if other imaging studies are normal. It may also be useful in distinguishing between radiation-induced and metastatic plexopathy. © 1999 Cancer Research Campaign

Keywords: brachial plexopathy, positron emission tomography, computerized tomography

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Selected References

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  1. Avril N., Dose J., Jänicke F., Bense S., Ziegler S., Laubenbacher C., Römer W., Pache H., Herz M., Allgayer B. Metabolic characterization of breast tumors with positron emission tomography using F-18 fluorodeoxyglucose. J Clin Oncol. 1996 Jun;14(6):1848–1857. doi: 10.1200/JCO.1996.14.6.1848. [DOI] [PubMed] [Google Scholar]
  2. Bagley F. H., Walsh J. W., Cady B., Salzman F. A., Oberfield R. A., Pazianos A. G. Carcinomatous versus radiation-induced brachial plexus neuropathy in breast cancer. Cancer. 1978 Jun;41(6):2154–2157. doi: 10.1002/1097-0142(197806)41:6<2154::aid-cncr2820410612>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  3. Cascino T. L., Kori S., Krol G., Foley K. M. CT of the brachial plexus in patients with cancer. Neurology. 1983 Dec;33(12):1553–1557. doi: 10.1212/wnl.33.12.1553. [DOI] [PubMed] [Google Scholar]
  4. Cooke J., Cooke D., Parsons C. The anatomy and pathology of the brachial plexus as demonstrated by computed tomography. Clin Radiol. 1988 Nov;39(6):595–601. doi: 10.1016/s0009-9260(88)80058-8. [DOI] [PubMed] [Google Scholar]
  5. Glazer H. S., Lee J. K., Levitt R. G., Heiken J. P., Ling D., Totty W. G., Balfe D. M., Emani B., Wasserman T. H., Murphy W. A. Radiation fibrosis: differentiation from recurrent tumor by MR imaging. Radiology. 1985 Sep;156(3):721–726. doi: 10.1148/radiology.156.3.4023233. [DOI] [PubMed] [Google Scholar]
  6. Huovinen R., Leskinen-Kallio S., Någren K., Lehikoinen P., Ruotsalainen U., Teräs M. Carbon-11-methionine and PET in evaluation of treatment response of breast cancer. Br J Cancer. 1993 Apr;67(4):787–791. doi: 10.1038/bjc.1993.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Okada J., Yoshikawa K., Itami M., Imaseki K., Uno K., Itami J., Kuyama J., Mikata A., Arimizu N. Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity. J Nucl Med. 1992 Mar;33(3):325–329. [PubMed] [Google Scholar]
  8. Panasci D. J., Holliday R. A., Shpizner B. Advanced imaging techniques of the brachial plexus. Hand Clin. 1995 Nov;11(4):545–553. [PubMed] [Google Scholar]
  9. Patronas N. J., Di Chiro G., Brooks R. A., DeLaPaz R. L., Kornblith P. L., Smith B. H., Rizzoli H. V., Kessler R. M., Manning R. G., Channing M. Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology. 1982 Sep;144(4):885–889. doi: 10.1148/radiology.144.4.6981123. [DOI] [PubMed] [Google Scholar]
  10. Rapoport S., Blair D. N., McCarthy S. M., Desser T. S., Hammers L. W., Sostman H. D. Brachial plexus: correlation of MR imaging with CT and pathologic findings. Radiology. 1988 Apr;167(1):161–165. doi: 10.1148/radiology.167.1.3347719. [DOI] [PubMed] [Google Scholar]
  11. Strauss L. G., Conti P. S. The applications of PET in clinical oncology. J Nucl Med. 1991 Apr;32(4):623–650. [PubMed] [Google Scholar]
  12. Strauss L. G., Conti P. S. The applications of PET in clinical oncology. J Nucl Med. 1991 Apr;32(4):623–650. [PubMed] [Google Scholar]
  13. Thyagarajan D., Cascino T., Harms G. Magnetic resonance imaging in brachial plexopathy of cancer. Neurology. 1995 Mar;45(3 Pt 1):421–427. doi: 10.1212/wnl.45.3.421. [DOI] [PubMed] [Google Scholar]
  14. Wahl R. L., Cody R. L., Hutchins G. D., Mudgett E. E. Primary and metastatic breast carcinoma: initial clinical evaluation with PET with the radiolabeled glucose analogue 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology. 1991 Jun;179(3):765–770. doi: 10.1148/radiology.179.3.2027989. [DOI] [PubMed] [Google Scholar]
  15. Wahl R. L., Quint L. E., Greenough R. L., Meyer C. R., White R. I., Orringer M. B. Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation. Radiology. 1994 May;191(2):371–377. doi: 10.1148/radiology.191.2.8153308. [DOI] [PubMed] [Google Scholar]
  16. Wahl R. L., Zasadny K., Helvie M., Hutchins G. D., Weber B., Cody R. Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography: initial evaluation. J Clin Oncol. 1993 Nov;11(11):2101–2111. doi: 10.1200/JCO.1993.11.11.2101. [DOI] [PubMed] [Google Scholar]

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