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. 1994 Jan;68(1):63–68. doi: 10.1128/jvi.68.1.63-68.1994

Sequence conservation in field and experimental isolates of Borna disease virus.

P A Schneider 1, T Briese 1, W Zimmermann 1, H Ludwig 1, W I Lipkin 1
PMCID: PMC236264  PMID: 8254777

Abstract

Coding and noncoding sequences were analyzed from field and experimental isolates of Borna disease virus. For a 24-kDa protein, maximum divergence was 1.5% at the predicted amino acid level and 3.1% at the nucleotide level. For a 40-kDa protein, maximum divergence was 1.1% at the predicted amino acid level and 4.1% at the nucleotide level. The highest variability in sequence (10%) was found in a 40-nucleotide stretch of genomic RNA between coding sequences for the 40- and 24-kDa proteins. The degree of sequence conservation in these isolates, passaged in various host species in vivo and in vitro over a period of 64 years, is unusual for negative-strand RNA viruses.

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Selected References

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