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. 1999 Feb;79(5-6):978–983. doi: 10.1038/sj.bjc.6690156

Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases

E Leygue 1, R E Hall 2, H Dotzlaw 1, P H Watson 3, L C Murphy 1
PMCID: PMC2362647  PMID: 10070900

Abstract

We have shown previously that the relative expression of a truncated oestrogen receptor-α variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-deleted and exon 7-deleted oestrogen receptor-α variant mRNAs in 15 primary breast tumour samples and in synchronous axillary lymph node metastases. Overall, there were no significant differences between the primary tumours and the matched metastases in the relative expression of these three specific variant mRNAs. Furthermore, the pattern of all deleted oestrogen receptor-α variant mRNAs appeared conserved between any primary and its matched secondary tumour. © 1999 Cancer Research Campaign

Keywords: oestrogen receptor-α, variants, breast cancer, metastasis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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