Abstract
Based on data from the Scottish Cancer Registry, the epidemiology of Kaposi's sarcoma (KS) in Scotland during the period 1976–96 is described. In males, the annual age-standardized incidence rate (World standard population) increased from less than 0.09 per 100 000 before 1986 to 0.44 in 1991 and then decreased to around 0.17. Peak incidence is now at ages 30–39 compared with ages 80+ during the period 1976–82; and by 1986–96 the standardized incidence ratio for the Health Board which includes Edinburgh had risen to almost four times the national level. These changes are largely consistent with the pattern of HIV infection in Scotland. However, in both sexes, relative to other neoplasms, and in international terms, KS remains rare in Scotland. For patients diagnosed during 1976–92, cumulative observed survival at 5 years was 8.7% at ages 0–49 compared with 49.8% at ages 50–84, reflecting the more aggressive course of AIDS-related KS, as well as the co-morbidity and competing causes of death associated with AIDS. © 1999 Cancer Research Campaign
Keywords: AIDS, epidemiology, incidence, Kaposi's sarcoma, Scotland
Full Text
The Full Text of this article is available as a PDF (75.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beral V., Bull D., Jaffe H., Evans B., Gill N., Tillett H., Swerdlow A. J. Is risk of Kaposi's sarcoma in AIDS patients in Britain increased if sexual partners came from United States or Africa? BMJ. 1991 Mar 16;302(6777):624–625. doi: 10.1136/bmj.302.6777.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California. MMWR Morb Mortal Wkly Rep. 1981 Jul 3;30(25):305–308. [PubMed] [Google Scholar]
- Dore G. J., Li Y., Grulich A. E., Hoy J. F., Mallal S. A., Mijch A. M., French M. A., Cooper D. A., Kaldor J. M. Declining incidence and later occurrence of Kaposi's sarcoma among persons with AIDS in Australia: the Australian AIDS cohort. AIDS. 1996 Oct;10(12):1401–1406. doi: 10.1097/00002030-199610000-00013. [DOI] [PubMed] [Google Scholar]
- Franceschi S., Dal Maso L., Lo Re A., Serraino D., La Vecchia C. Trends of Kaposi's sarcoma at AIDS diagnosis in Europe and the United States, 1987-94. Br J Cancer. 1997;76(1):114–117. doi: 10.1038/bjc.1997.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goldberg D., Davis B., Allardice G., McMenamin J., Codere G. Monitoring the spread of HIV and AIDS in Scotland 1983-1994. Scott Med J. 1996 Oct;41(5):131–138. doi: 10.1177/003693309604100501. [DOI] [PubMed] [Google Scholar]
- Grulich A. E., Beral V., Swerdlow A. J. Kaposi's sarcoma in England and Wales before the AIDS epidemic. Br J Cancer. 1992 Dec;66(6):1135–1137. doi: 10.1038/bjc.1992.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hermans P., Lundgren J., Sommereijns B., Pedersen C., Vella S., Katlama C., Lüthy R., Pinching A. J., Gerstoft J., Pehrson P. Epidemiology of AIDS-related Kaposi's sarcoma in Europe over 10 years. AIDS in Europe Study Group. AIDS. 1996 Jul;10(8):911–917. [PubMed] [Google Scholar]
- Junor B. J. The need for renal replacement therapy in Scotland. Health Bull (Edinb) 1996 Nov;54(6):474–485. [PubMed] [Google Scholar]
- Michaels S. H., Clark R., Kissinger P. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med. 1998 Aug 6;339(6):405–406. doi: 10.1056/NEJM199808063390612. [DOI] [PubMed] [Google Scholar]
- Moore P. S., Chang Y. Kaposi's sarcoma (KS), KS-associated herpesvirus, and the criteria for causality in the age of molecular biology. Am J Epidemiol. 1998 Feb 1;147(3):217–221. doi: 10.1093/oxfordjournals.aje.a009440. [DOI] [PubMed] [Google Scholar]
- Walker D., Smith I. M., Jones I. G. Adult heart-lung and lung transplantation in Scotland. Scott Med J. 1996 Aug;41(4):101–103. doi: 10.1177/003693309604100402. [DOI] [PubMed] [Google Scholar]
